Лаборатория клеточной нейробиологии обучения

Краткая история и основные направления научной работы лаборатории

Лаборатория была создана в 1989 году на основе группы, проводившей исследования на беспозвоночных животных, входившей в состав лаборатории академика П.В.Симонова.
Основные направления научной работы – клеточные механизмы организации поведения и модификаций поведения в результате обучения, клеточные и молекулярные механизмы памяти. Наряду с традиционными электрофизиологическими методами в лаборатории активно применяются оптические методы регистрации и конфокальная микроскопия. В качестве объекта исследования используются животные с простой нервной системой или срезы мозга позвоночных животных.
Международное сотрудничество – с Йельским Университетом (США) в области оптических методов, с Аризонским Университетом (США) в области анализа нейронных сетей крылоногих моллюсков, с Институтом нейрофизиологии Университета в Бохуме (Германия) и c университетом Коннектикута (США) в области синаптических механизмов пластичности.

Книги

Балабан П.М. Сравнительная физиология памяти. Актуальные проблемы современной физиологии. 2016, изд. Цвет в цифре, Казань 270 стр., стр. 87-101.
Балабан П.М. Принципы организации нервной системы: механизмы обучения и памяти в простых системах, с.12-24. В: Избранные главы фундаментальной и трансляционной медицины / отв. ред. Р.И. Жданов. – Казань: Изд-во Казан. ун-та, 2014. – 592 с. ISBN 987-5-00019-266-5
Тухбатова Г.Р., Гуляев М.В., Свинов М.М., Саложин С.В., Балабан П.М. Применение технологии лентивирусной трансдукции для сравнительного анализа нейропротекторной активности трофических факторов при моделировании острого нарушения мозгового кровообращения в локальных областях мозга. Нейродегенеративные заболевания: от генома до целостного организма // под ред. М.В. Угрюмова. – в 2-х томах - М. : Научный мир, 2014. ISBN 978-591522-400-0
Balaban P.M. (2002) Declarative and procedural memory in animals with simple nervous systems. In: "Psychology at the turn of the millennium, Vol. 1: Cognitive, biological, and health perspectives" (Eds: Lars Bäckman & Claes von Hofsten). Psychology Press, pp. 1-28.
Balaban P.M. Applicability of the reinforcement concept to studies in simple nervous systems. In: Complex Brain Functions. Conceptual Advances in Russian Neuroscience. Eds. A.M.Ivanitsky, P.M.Balaban, Harwood Academic Publishers, 2000, p.201-211.

Список сотрудников

Список публикаций

Статьи

Anikin A., Aseyev N.A., Johansson N. Do some languages sound more beautiful than others?. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023. V. 120. N. 17. e2218367120. DOI: 10.1073/pnas.2218367120
Aseyev N.A. Perception of color in primates: A conceptual color neurons hypothesis. Bio Systems. 2023. V. 225. P. 104867. DOI: 10.1016/j.biosystems.2023.104867
Moroz L.L., Mukherjee K., Romanova D. Nitric oxide signaling in ctenophores. Frontiers In Neuroscience. 2023. V. 17. P. 1125433. DOI: 10.3389/fnins.2023.1125433
Nikitin M.A., Romanova D., Borman S.I., Moroz L.L. Amino acids integrate behaviors in nerveless placozoans. Frontiers In Neuroscience. 2023. V. 17. P. 1125624. DOI: 10.3389/fnins.2023.1125624
Talantseva O.I., Portnova G.V., Romanova D.Y., Martynova O.V., Sysoeva O.V., Grigorenko E.L. Does the Potocki-Lupski Syndrome Convey the Autism Spectrum Disorder Phenotype? Case Report and Scoping Review. Journal Of Personalized Medicine. 2023. V. 13. N. 3. P. 439. DOI: 10.3390/jpm13030439
Aseyev N.A. Morphological and electrophysiological evidences of synaptic switching in vestibular nerve of land snail Helix lucorum L. Biochemical And Biophysical Research Communications. 2022. V. 611. P. 114-117. DOI: 10.1016/j.bbrc.2022.04.026
Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Nav1.6 but not KCa3.1 channels contribute to heterogeneity in coding abilities and dynamics of action potentials in the L5 neocortical pyramidal neurons. Biochemical And Biophysical Research Communications. 2022. V. 615. P. 102-108. DOI: 10.1016/j.bbrc.2022.05.050
Kost L.A., Iunusova V.A., Ivanova V.O., Nikitin E.S., Lukyanov K.A., Bogdanov A.M. The Electromotive Protein Prestin as a Sensitive Core of the Fluorescent Voltage Indicator. Russian Journal of Bioorganic Chemistry. 2022. V. 48. N. 3. P. 617-620. DOI: 10.1134/S1068162022030098
Moroz L.L., Romanova D. Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans). Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 1071961. DOI: 10.3389/fcell.2022.1071961
Romanova D., Nikitin M.A., Shchenkov S.V., Moroz L.L. Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing of Trichoplax and Hoilungia. Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 823283. DOI: 10.3389/fcell.2022.823283
Romanova D.Y., Balaban P.M., Nikitin E.S. Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons . Biophysica. 2022. V. 2. N. 3. P. 184-193. DOI: 10.3390/biophysica2030019
Simonova N.A., Volgushev M.A., Malyshev A.Y. Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats. Frontiers In Synaptic Neuroscience. 2022. V. 14. P. 889947. DOI: 10.3389/fnsyn.2022.889947
Smirnova G.R., Medvedeva T.M., Pavlova I.V., Vinogradova L.V. Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization. Biomedicines. 2022. V. 10. N. 9. P. 2183. DOI: 10.3390/biomedicines10092183
Chasse R., Malyshev A.Y., Fitch R.H., Volgushev M.A. Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice. The Journal Of Neuroscience. 2021. V. 41. N. 21. P. 4631-4640. DOI: 10.1523/JNEUROSCI.3073-20.2021
Gyori J., Kohn A.B., Romanova D., Moroz L.L. ATP signaling in the integrative neural center of Aplysia californica. Scientific Reports. 2021. V. 11. N. 1. P. 5478. DOI: 10.1038/s41598-021-84981-5
Idzhilova O.S., Roshchin M.V., Smirnova G.R., Malyshev A.Y. Central Targeting of Channelrhodopsin2 by the Motif of Potassium Channel Kv2.1 Can be Altered Due to Overexpression of the Construct. BioNanoScience. 2021. V. 11. N. 2. P. 408-416. DOI: 10.1007/s12668-021-00863-0
Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.V. Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Molecular Biology Reports. 2021. V. 48. N. 5. P. 4549-4561. DOI: 10.1007/s11033-021-06480-0
Moroz L.L., Nikitin E.S., Policar P.G., Kohn A.B., Romanova D. Evolution of glutamatergic signaling and synapses. Neuropharmacology. 2021. V. 199. P. 108740. DOI: 10.1016/j.neuropharm.2021.108740
Moroz L.L., Romanova D. Selective Advantages of Synapses in Evolution. Frontiers In Cell And Developmental Biology. 2021. V. 9. P. 726563. DOI: 10.3389/fcell.2021.726563
Moroz L.L., Romanova D., Kohn A.B. Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters. Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. 2021. V. 376. N. 1821. P. 20190762. DOI: 10.1098/rstb.2019.0762
Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263
Polinski J.M., Zimin A.V., Clark K.F., Kohn A.B., Sadowski N., Timp W., Ptitsyn A., Khanna P., Romanova D., Williams P., Greenwood S.J., Moroz L.L., Walt D.R., Bodnar A.G. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Science Advances. 2021. V. 7. N. 26. eabe8290. DOI: 10.1126/sciadv.abe8290
Romanova D., Varoqueaux F., Daraspe J., Nikitin E.S., Eitel M., Fasshauer D., Moroz L.L. Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis. Cell And Tissue Research. 2021. V. 385. N. 3. P. 623-637. DOI: 10.1007/s00441-021-03459-y
Бородинова А.А., Балабан П.М. Эпигенетическая регуляция как основа долговременных изменений в нервной системе: в поисках механизмов специфичности. Биохимия. 2020. T. 85. № 9. С. 1139-1158. DOI: 10.31857/S0320972520090018
Ермакова Ю.Г., Рощин М.В., Ланин А.А., Балабан П.М., Желтиков А.М., Белоусов В.В., Никитин Е.С. ТЕРМОГЕНЕТИКА КАК НОВОЕ НАПРАВЛЕНИЕ КОНТРОЛЯ АКТИВНОСТИ НЕЙРОННОЙ СЕТИ. ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА. 2020. T. 70. № 1. С. 133-140. DOI: 10.31857/S0044467720010050
Balaban P.M., Borodinova A.A. Neurogenetic Technologies for Research on the Mechanisms Maintaining Memory. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1057-1064. DOI: 10.1007/s11055-020-01005-x
Borodinova A.A., Balaban P.M. Epigenetic Regulation as a Basis for Long-Term Changes in the Nervous System: In Search of Specificity Mechanisms. Biochemistry (Moscow). 2020. V. 85. N. 9. P. 994-1010. DOI: 10.1134/S0006297920090023
Ivanova V.O., Bal N.V., Balaban P.M. Modulation of AMPA receptors by nitric oxide in nerve cells. International Journal of Molecular Sciences. 2020. V. 21. N. 3. DOI: 10.3390/ijms21030981
Malyshev A.Y., Ostrovsky M.A. Experience in the Use of Optogenetic Approaches to Studies of Brain Functions and Prosthetization of Degenerative Retinas. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1065-1071. DOI: 10.1007/s11055-020-01006-w
Moroz L.L., Romanova D., Nikitin E.S., Sohn D., Kohn A.B., Neveu E., Varoqueaux F., Fasshauer D. The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission. Scientific Reports. 2020. V. 10. N. 1. P. 13020. DOI: 10.1038/s41598-020-69851-w
Moroz L.L., Sohn D., Romanova D., Kohn A.B. Microchemical identification of enantiomers in early-branching animals: Lineage-specific diversification in the usage of D-glutamate and D-aspartate. Biochemical And Biophysical Research Communications. 2020. V. 527. N. 4. P. 947-952. DOI: 10.1016/j.bbrc.2020.04.135
Pfeiffer P., Egorov A.V., Lorenz F., Schleimer J.H., Draguhn A., Schreiber S. Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory. ELife. 2020. V. 9. e49974. DOI: 10.7554/eLife.49974
Romanova D. Glycine as a signaling molecule and chemoattractant in Trichoplax (Placozoa): insights into the early evolution of neurotransmitters. NeuroReport. 2020. V. 31. N. 6. P. 490-497. DOI: 10.1097/WNR.0000000000001436
Romanova D.Y., Smirnov K.S., Nikitin M.A., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020
Roshchin M.V., Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Ca(2+)-activated KCa3.1 potassium channels contribute to the slow afterhyperpolarization in L5 neocortical pyramidal neurons. Scientific Reports. 2020. V. 10. N. 1. P. 14484. DOI: 10.1038/s41598-020-71415-x
Балабан П.М., Бородинова А.А. Нейрогенетические технологии исследования механизмов хранения памяти. Рос. физиол. журн . им. И.М. Сеченова. 2019. T. 105. № 11. С. 1392-1405. DOI: 10.1134/S0869813919110025
Borodinova A.A., Kuznetsova M.A., Alekseeva V.S., Balaban P.M. Histone acetylation determines transcription of atypical protein kinases in rat neurons. Scientific Reports. 2019. V. 9. N. 1. P. 4332. DOI: 10.1038/s41598-019-40823-z
Chesnokova E., Zuzina A., Bal N., Vinarskaya A., Roshchin M., Artyuhov A., Dashinimaev E., Aseyev N., Balaban P., Kolosov P. Experiments with Snails Add to Our Knowledge about the Role of aPKC Subfamily Kinases in Learning. International Journal Of Molecular Sciences. 2019. V. 20. N. 9. P. 2117. DOI: 10.3390/ijms20092117
Egorov A.V., Schumacher D., Medert R., Birnbaumer L., Freichel M., Draguhn A. TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019. V. 29. N. 11. P. 1038-1048. DOI: 10.1002/hipo.23094
Ivanova V.O., Bal N.V., Balaban P.M. Nitric oxide is involved in the mechanism of ampa receptors incorporation into dendrites of pyramidal neurons in hippocampus . // BNA Festival of Neuroscience 2019. 2019. V. 3. PT039 (SP) .
Johansson N., Anikin A., Aseyev N.A. Color sound symbolism in natural languages. Language and Cognition. 2019. V. 12. N. 1. P. 56-83. DOI: 10.1017/langcog.2019.35
Kost L.A., Ivanova V.O., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.M. Red Fluorescent Genetically Encoded Voltage Indicators with Millisecond Responsiveness. Sensors (Basel, Switzerland). 2019. V. 19. N. 13. P. 2982. DOI: 10.3390/s19132982
Maltsev A.V., Bal N.V., Balaban P.M. LTP suppression by protein synthesis inhibitors is NO-dependent. Neuropharmacology. 2019. V. 146. P. 276-288. DOI: 10.1016/j.neuropharm.2018.12.009
Malyshev A.Y., Balaban P.M. More Light on the Brain: 30 Years Later. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 2. P. 159-162. DOI: 10.1007/s11055-019-00728-w
Nikitin E.S., Roschin V.Y., Ierusalimsky V.N., Egorov A.V., Balaban P.M. Optogenetic Stimulation of the Axons of Visual Cortex and Hippocampus Pyramidal Neurons in Living Brain Slices. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 2. P. 227-232. DOI: 10.1007/s11055-019-00719-x
Smirnova G.R., Roshchin M.V., Vinarskaya A.Kh., Kolotova D.Y., Simonova N.A., Balaban P.M., Malyshev A.Y. Use of Anchoring Motifs to Support the Central and Peripheral Locations of Opsins in Optogenetics. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 9. P. 1089-1091. DOI: 10.1007/s11055-019-00843-8
Tyshkovskiy A., Bozaykut P., Borodinova A.A., Gerashchenko M.V., Ables G.P., Garratt M., Khaitovich P., Clish C.B., Miller R.A., Gladyshev V.N. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metabolism. 2019. V. 30. P. 573-593. DOI: 10.1016/j.cmet.2019.06.018
Xu C., Li Q., Efimova O., Petrova M., Vinarskaya A.Kh., Kolosov P.M., Aseyev N.A., Koshkareva K., Ierusalimsky V.N., Balaban P.M., Khaitovich P. Identification of immediate early genes in the nervous system of snail Helix lucorum. eNeuro. 2019. ENEURO.0416-18.2019. DOI: 10.1523/ENEURO.0416-18.2019
Благирев А.А., Чеснокова Е.А., Баль Н.В., Колосов П.М. Транскрипция отдельных нейронов. Журнал высшей нервной деятельности им. И.П. Павлова. 2018. T. 68. № 6. С. 675-702. DOI: 10.1134/S0044467718060047
Dobryakova Y.V., Kasianov A., Zaichenko M.I., Stepanichev M.Y., Chesnokova E.A., Kolosov P.M., Markevich V.A., Bolshakov A.P. Intracerebroventricular administration of <sup>192</sup>IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Frontiers in Molecular Neuroscience. 2018. V. 10. P. 429. DOI: 10.3389/fnmol.2017.00429