Романова Дарья Юрьевна

нс, кбн

эволюция, нервная система, происхождение нейрона

Лаборатория клеточной нейробиологии обучения

Scopus ID: 57215000681
ORCID ID: 0000-0002-7508-3969
Web of Science ResearcherID: AAL-7453-2020
SPIN-код РИНЦ: 8540-2824

Исследование клеточных и молекулярных основ поведения у Пластинчатых, Гребневиков и моллюсков является важным для анализа эволюции и функционального биоразнообразия животных в целом, с фокусом на формирование их интеграционных и нервных систем. Интегрируя методы современной филогеномики, технологии секвенирования транскриптомов единичных клеток (scRNA-seq), машинного обучения, изучения протеомики и метаболомики на уровне отдельных клеток у многоклеточных животных, можно реконструировать генеалогию клеточных типов, прослеживая ее вплоть до представителей базовых Многоклеточных на примере простейшей клеточной организации.

Руководство НИР

РНФ: №23-14-00050 “Геномные и клеточные основы поведения у безнервных животных”

Список публикаций

Статьи

Li Y., Sun C., Romanova D., Wu D.O., Fang R., Moroz L.L. Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial. Methods in Molecular Biology. 2024. V. 2757. P. 383-445. DOI: 10.1007/978-1-0716-3642-8_17
Nikitin M.A., Romanova D., Moroz L.L. Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax. Methods in Molecular Biology. 2024. V. 2757. P. 531-581. DOI: 10.1007/978-1-0716-3642-8_22
Romanova D., Moroz L.L. Parallel evolution of gravity sensing. Frontiers in Cell and Developmental Biology. 2024. V. 12. DOI: 10.3389/fcell.2024.1346032
Romanova D., Moroz L.L. Brief History of Placozoa. Methods in Molecular Biology. 2024. V. 2757. P. 103-122. DOI: 10.1007/978-1-0716-3642-8_3
Romanova D., Varoqueaux F., Eitel M., Yoshida M.A., Nikitin M.A., Moroz L.L. Long-Term Culturing of Placozoans (Trichoplax and Hoilungia). Methods in Molecular Biology. 2024. V. 2757. P. 509-529. DOI: 10.1007/978-1-0716-3642-8_21
Moroz L.L., Mukherjee K., Romanova D. Nitric oxide signaling in ctenophores. Frontiers In Neuroscience. 2023. V. 17. P. 1125433. DOI: 10.3389/fnins.2023.1125433
Moroz L.L., Romanova D. Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals. Animal Cognition. 2023. P. 1-14. DOI: 10.1007/s10071-023-01833-7
Moroz L.L., Romanova D. Homologous vs. Homocratic Neurons: Revisiting Complex Evolutionary Trajectories. Frontiers in Cell and Developmental Biology. 2023. V. 11. P. 1336093. DOI: 10.3389/fcell.2023.1336093
Nikitin M.A., Romanova D., Borman S.I., Moroz L.L. Amino acids integrate behaviors in nerveless placozoans. Frontiers In Neuroscience. 2023. V. 17. P. 1125624. DOI: 10.3389/fnins.2023.1125624
Moroz L.L., Romanova D. Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans). Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 1071961. DOI: 10.3389/fcell.2022.1071961
Romanova D., Nikitin M.A., Shchenkov S.V., Moroz L.L. Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing of Trichoplax and Hoilungia. Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 823283. DOI: 10.3389/fcell.2022.823283
Romanova D.Y., Balaban P.M., Nikitin E.S. Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons . Biophysica. 2022. V. 2. N. 3. P. 184-193. DOI: 10.3390/biophysica2030019
Gyori J., Kohn A.B., Romanova D., Moroz L.L. ATP signaling in the integrative neural center of Aplysia californica. Scientific Reports. 2021. V. 11. N. 1. P. 5478. DOI: 10.1038/s41598-021-84981-5
Moroz L.L., Nikitin M.A., Policar P.G., Kohn A.B., Romanova D. Evolution of glutamatergic signaling and synapses. Neuropharmacology. 2021. V. 199. P. 108740. DOI: 10.1016/j.neuropharm.2021.108740
Moroz L.L., Romanova D. Selective Advantages of Synapses in Evolution. Frontiers In Cell And Developmental Biology. 2021. V. 9. P. 726563. DOI: 10.3389/fcell.2021.726563
Moroz L.L., Romanova D., Kohn A.B. Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters. Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. 2021. V. 376. N. 1821. P. 20190762. DOI: 10.1098/rstb.2019.0762
Polinski J.M., Zimin A.V., Clark K.F., Kohn A.B., Sadowski N., Timp W., Ptitsyn A., Khanna P., Romanova D., Williams P., Greenwood S.J., Moroz L.L., Walt D.R., Bodnar A.G. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Science Advances. 2021. V. 7. N. 26. eabe8290. DOI: 10.1126/sciadv.abe8290
Romanova D., Varoqueaux F., Daraspe J., Nikitin M.A., Eitel M., Fasshauer D., Moroz L.L. Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis. Cell And Tissue Research. 2021. V. 385. N. 3. P. 623-637. DOI: 10.1007/s00441-021-03459-y
Moroz L.L., Romanova D., Nikitin M.A., Sohn D., Kohn A.B., Neveu E., Varoqueaux F., Fasshauer D. The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission. Scientific Reports. 2020. V. 10. N. 1. P. 13020. DOI: 10.1038/s41598-020-69851-w
Moroz L.L., Sohn D., Romanova D., Kohn A.B. Microchemical identification of enantiomers in early-branching animals: Lineage-specific diversification in the usage of D-glutamate and D-aspartate. Biochemical And Biophysical Research Communications. 2020. V. 527. N. 4. P. 947-952. DOI: 10.1016/j.bbrc.2020.04.135
Romanova D. Glycine as a signaling molecule and chemoattractant in Trichoplax (Placozoa): insights into the early evolution of neurotransmitters. NeuroReport. 2020. V. 31. N. 6. P. 490-497. DOI: 10.1097/WNR.0000000000001436
Romanova D.Y., Smirnov K.S., Nikitin M.A., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020