Лаборатория клеточной нейробиологии обучения
Краткая история и основные направления научной работы лаборатории
Лаборатория была создана в 1989 году на основе группы, проводившей исследования на беспозвоночных животных, входившей в состав лаборатории академика П.В.Симонова.
Основные направления научной работы – клеточные механизмы организации поведения и модификаций поведения в результате обучения, клеточные и молекулярные механизмы памяти. Наряду с традиционными электрофизиологическими методами в лаборатории активно применяются оптические методы регистрации и конфокальная микроскопия. В качестве объекта исследования используются животные с простой нервной системой или срезы мозга позвоночных животных.
Международное сотрудничество – с Йельским Университетом (США) в области оптических методов, с Аризонским Университетом (США) в области анализа нейронных сетей крылоногих моллюсков, с Институтом нейрофизиологии Университета в Бохуме (Германия) и c университетом Коннектикута (США) в области синаптических механизмов пластичности.
Книги
- Балабан П.М. Сравнительная физиология памяти. Актуальные проблемы современной физиологии. 2016, изд. Цвет в цифре, Казань 270 стр., стр. 87-101.
- Балабан П.М. Принципы организации нервной системы: механизмы обучения и памяти в простых системах, с.12-24. В: Избранные главы фундаментальной и трансляционной медицины / отв. ред. Р.И. Жданов. – Казань: Изд-во Казан. ун-та, 2014. – 592 с. ISBN 987-5-00019-266-5
- Тухбатова Г.Р., Гуляев М.В., Свинов М.М., Саложин С.В., Балабан П.М. Применение технологии лентивирусной трансдукции для сравнительного анализа нейропротекторной активности трофических факторов при моделировании острого нарушения мозгового кровообращения в локальных областях мозга. Нейродегенеративные заболевания: от генома до целостного организма // под ред. М.В. Угрюмова. – в 2-х томах - М. : Научный мир, 2014. ISBN 978-591522-400-0
- Balaban P.M. (2002) Declarative and procedural memory in animals with simple nervous systems. In: "Psychology at the turn of the millennium, Vol. 1: Cognitive, biological, and health perspectives" (Eds: Lars Bäckman & Claes von Hofsten). Psychology Press, pp. 1-28.
- Balaban P.M. Applicability of the reinforcement concept to studies in simple nervous systems. In: Complex Brain Functions. Conceptual Advances in Russian Neuroscience. Eds. A.M.Ivanitsky, P.M.Balaban, Harwood Academic Publishers, 2000, p.201-211.
Список сотрудников
Список публикаций
Статьи
- Bal N.V., Beletskiy A.P., Volobueva M.N., Ivanova V.O., Shvadchenko A. Changes in gene expression in dorsal and ventral CA1 areas and dentate gyrus in male mice hippocampus due to context fear conditioning. Neuroscience and Behavioral Physiology. 2025. V. 55. N. 1. P. 74-85. DOI: 10.1007/s11055-024-01749-w
- Bal N.V., Oblasov I., Ierusalimsky V.N., Shvadchenko A.M., Fortygina P., Idzhilova O.S., Borodinova A.A., Balaban P.M., Feofanov A.V., Nekrasova O.V., Nikitin E.S. Potassium KCa3.1 channel overexpression deteriorates functionality and availability of channels at the outer cellular membrane. Scientific Reports. 2025. V. 15. N. 1. P. 4928. DOI: 10.1038/s41598-025-89097-8
- Chesnokova E., Bal N.V., Alhalabi G., Balaban P.M. Regulatory Elements for Gene Therapy of Epilepsy. Cells. 2025. V. 14. N. 3. P. 236. DOI: 10.3390/cells14030236
- Romshin A.M., Aseyev N.A., Idzhilova O.S., Koryagina A.A., Zeeb V.E., Vlasov I.I., Balaban P.M. Rapid neurostimulation at the micron scale with an optically controlled thermal-capture technique. Biomaterials Science. 2025. V. 13. N. 1. P. 250-260. DOI: 10.1039/D4BM01114G
- Aseyev N.A., Borodinova A.A., Pavlova S.A., Roshchina M.A., Roshchin M.V., Nikitin E.S., Balaban P.M. CADENCE - Neuroinformatics Tool for Supervised Calcium Events Detection. Neuroinformatics. 2024. DOI: 10.1007/s12021-024-09677-3
- Li Y., Sun C., Romanova D., Wu D.O., Fang R., Moroz L.L. Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial. Methods in Molecular Biology. 2024. V. 2757. P. 383-445. DOI: 10.1007/978-1-0716-3642-8_17
- Luponosov Y.N., Solodukhin A.N., Aseyev N.A., Rokitskaya T.I., Kolotova D.Y., Kotova E.A., Kurkin T.S., Poletavkina L.A., Isaeva Y.A., Antonenko Y.N., Balaban P.M., Ponomarenko S.A. Nanoparticles of Push-Pull Triphenylamine-Based Molecules for Light-Controlled Stimulation of Neuronal Activity. ACS Biomaterials Science & Engineering. 2024. V. 10. N. 2. P. 1139-1152. DOI: 10.1021/acsbiomaterials.3c01562
- Medvedeva T.M., Smirnova G.R., Pavlova I.V., Vinogradova L.V. Different vulnerability of fast and slow cortical oscillations to suppressive effect of spreading depolarization: state-dependent features potentially relevant to pathogenesis of migraine aura. The Journal Of Headache And Pain. 2024. V. 25. N. 1. P. 8. DOI: 10.1186/s10194-023-01706-x
- Nikitin M.A., Romanova D., Moroz L.L. Bioinformatic Prohormone Discovery in Basal Metazoans: Insights from Trichoplax. Methods in Molecular Biology. 2024. V. 2757. P. 531-581. DOI: 10.1007/978-1-0716-3642-8_22
- Oblasov I., Bal N.V., Shvadchenko A.M., Fortygina P., Idzhilova O.S., Balaban P.M., Nikitin E.S. Ca(2+)-permeable AMPA receptor-dependent silencing of neurons by KCa3.1 channels during epileptiform activity. Biochemical And Biophysical Research Communications. 2024. V. 733. P. 150434. DOI: 10.1016/j.bbrc.2024.150434
- Romanova D., Moroz L.L. Parallel evolution of gravity sensing. Frontiers in Cell and Developmental Biology. 2024. V. 12. DOI: 10.3389/fcell.2024.1346032
- Romanova D., Moroz L.L. Brief History of Placozoa. Methods in Molecular Biology. 2024. V. 2757. P. 103-122. DOI: 10.1007/978-1-0716-3642-8_3
- Romanova D., Varoqueaux F., Eitel M., Yoshida M.A., Nikitin M.A., Moroz L.L. Long-Term Culturing of Placozoans (Trichoplax and Hoilungia). Methods in Molecular Biology. 2024. V. 2757. P. 509-529. DOI: 10.1007/978-1-0716-3642-8_21
- Anikin A., Aseyev N.A., Johansson N. Do some languages sound more beautiful than others?. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2023. V. 120. N. 17. e2218367120. DOI: 10.1073/pnas.2218367120
- Aseyev N., Ivanova V., Balaban P., Nikitin E. Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies. Biosensors. 2023. V. 13. N. 6. P. 648. DOI: 10.3390/bios13060648
- Aseyev N.A. Perception of color in primates: A conceptual color neurons hypothesis. Bio Systems. 2023. V. 225. P. 104867. DOI: 10.1016/j.biosystems.2023.104867
- Borodinova A., Ierusalimsky V., Balaban P. Comparison of the Transduction Capacity of AAV5 and AAV PHP.eB Serotypes in Hippocampus Astroglia. Neuroglia. 2023. V. 4. N. 4. P. 275-289. DOI: 10.3390/neuroglia4040019
- Ierusalimsky V.N., Karimova E.D., Samotaeva I.S., Luzin R., Zinchuk M., Rider F., Guekht A. Structural brain changes in patients with temporal lobe epilepsy and comorbid depression. Zhurnal Nevrologii I Psihiatrii Imeni S S Korsakova. 2023. V. 123. N. 9. P. 83-89. DOI: 10.17116/jnevro202312309183
- Maltsev A.V., Funikov S., Rezvykh A., Teterina E., Nebogatikov V., Burov A., Bal N.V., Ustyugov A., Karpov V., Morozov A. Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates. International Journal Of Molecular Sciences. 2023. V. 24. N. 9. P. 8172. DOI: 10.3390/ijms24098172
- Moroz L.L., Mukherjee K., Romanova D. Nitric oxide signaling in ctenophores. Frontiers In Neuroscience. 2023. V. 17. P. 1125433. DOI: 10.3389/fnins.2023.1125433
- Moroz L.L., Romanova D. Chemical cognition: chemoconnectomics and convergent evolution of integrative systems in animals. Animal Cognition. 2023. P. 1-14. DOI: 10.1007/s10071-023-01833-7
- Moroz L.L., Romanova D. Homologous vs. Homocratic Neurons: Revisiting Complex Evolutionary Trajectories. Frontiers in Cell and Developmental Biology. 2023. V. 11. P. 1336093. DOI: 10.3389/fcell.2023.1336093
- Nikitin E.S., Postnikova T.Y., Proskurina E.Y., Borodinova A.A., Ivanova V.O., Roshchin M.V., Smirnova G.R., Kelmanson I., Belousov V.V., Balaban P.M., Zaitsev A.V. Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability. Gene Therapy. 2023. DOI: 10.1038/s41434-023-00427-9
- Nikitin M.A., Romanova D., Borman S.I., Moroz L.L. Amino acids integrate behaviors in nerveless placozoans. Frontiers In Neuroscience. 2023. V. 17. P. 1125624. DOI: 10.3389/fnins.2023.1125624
- Talantseva O.I., Portnova G.V., Romanova D.Y., Martynova O.V., Sysoeva O.V., Grigorenko E.L. Does the Potocki-Lupski Syndrome Convey the Autism Spectrum Disorder Phenotype? Case Report and Scoping Review. Journal Of Personalized Medicine. 2023. V. 13. N. 3. P. 439. DOI: 10.3390/jpm13030439
- Aseyev N.A. Morphological and electrophysiological evidences of synaptic switching in vestibular nerve of land snail Helix lucorum L. Biochemical And Biophysical Research Communications. 2022. V. 611. P. 114-117. DOI: 10.1016/j.bbrc.2022.04.026
- Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Nav1.6 but not KCa3.1 channels contribute to heterogeneity in coding abilities and dynamics of action potentials in the L5 neocortical pyramidal neurons. Biochemical And Biophysical Research Communications. 2022. V. 615. P. 102-108. DOI: 10.1016/j.bbrc.2022.05.050
- Kost L.A., Iunusova V.A., Ivanova V.O., Nikitin E.S., Lukyanov K.A., Bogdanov A.M. The Electromotive Protein Prestin as a Sensitive Core of the Fluorescent Voltage Indicator. Russian Journal of Bioorganic Chemistry. 2022. V. 48. N. 3. P. 617-620. DOI: 10.1134/S1068162022030098
- Maltsev A.V., Nikiforova A.B., Bal N.V., Balaban P.M. Amyloid Aβ(25-35) Aggregates Say 'NO' to Long-Term Potentiation in the Hippocampus through Activation of Stress-Induced Phosphatase 1 and Mitochondrial Na(+)/Ca(2+) Exchanger. International Journal Of Molecular Sciences. 2022. V. 23. N. 19. P. 11848. DOI: 10.3390/ijms231911848
- Maltsev A.V., Roshchin M.V., Bezprozvanny I., Smirnov I.V., Vlasova O., Balaban P.M., Borodinova A.A. Bidirectional regulation by "star forces": Ionotropic astrocyte's optical stimulation suppresses synaptic plasticity, metabotropic one strikes back. Hippocampus. 2022. V. 33. N. 1. P. 18-36. DOI: 10.1002/hipo.23486
- Moroz L.L., Romanova D. Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans). Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 1071961. DOI: 10.3389/fcell.2022.1071961
- Nikitin E.S., Roshchin M.V., Borodinova A.A., Zuzina A.B., Balaban P.M. EMPLOYMENT OF OPTICAL PROBES FOR THE IMAGING OF INTRACELLULAR CALCIUM AND ACTION POTENTIAL IN NEURONS. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2022. V. 72. N. 2. P. 149-158. DOI: 10.31857/S0044467722010075
- Romanova D., Nikitin M.A., Shchenkov S.V., Moroz L.L. Expanding of Life Strategies in Placozoa: Insights From Long-Term Culturing of Trichoplax and Hoilungia. Frontiers In Cell And Developmental Biology. 2022. V. 10. P. 823283. DOI: 10.3389/fcell.2022.823283
- Romanova D.Y., Balaban P.M., Nikitin E.S. Sodium Channels Involved in the Initiation of Action Potentials in Invertebrate and Mammalian Neurons . Biophysica. 2022. V. 2. N. 3. P. 184-193. DOI: 10.3390/biophysica2030019
- Roshchina M.A., Borodinova A.A., Roshchin M.V. Influence of histone deacetylases inhibitor sodium butyrate on hippocampal neuronal activity in vivo. Neuroscience and Behavioral Physiology. 2022. V. 52. 769–777. DOI: 10.1007/s11055-022-01240-4
- Shvadchenko A.M., Volobueva M.N., Ivanova V.O., Beletskiy A.P., Smirnova G.R., Bal N.V., Balaban P.M. New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas. Biochemistry Moscow. 2022. V. 87. N. 11. P. 1243-1251. DOI: 10.1134/S0006297922110037
- Simonova N.A., Volgushev M.A., Malyshev A.Y. Enhanced Non-Associative Long-Term Potentiation in Immature Granule Cells in the Dentate Gyrus of Adult Rats. Frontiers In Synaptic Neuroscience. 2022. V. 14. P. 889947. DOI: 10.3389/fnsyn.2022.889947
- Smirnova G.R., Medvedeva T.M., Pavlova I.V., Vinogradova L.V. Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization. Biomedicines. 2022. V. 10. N. 9. P. 2183. DOI: 10.3390/biomedicines10092183
- Beletskiy A., Chesnokova E., Bal N.V. Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent and Memory Enhancer-Its Comparative Expression, Processing and Signaling in Mammalian CNS. International Journal Of Molecular Sciences. 2021. V. 22. N. 4. P. 1849. DOI: 10.3390/ijms22041849
- Borodinova A.A., Balaban P.M., Bezprozvanny I.B., Salmina A.B., Vlasova O.L. Genetic Constructs for the Control of Astrocytes' Activit. Cells. 2021. V. 10. N. 7. P. 1600. DOI: 10.3390/cells10071600
- Chasse R., Malyshev A.Y., Fitch R.H., Volgushev M.A. Altered Heterosynaptic Plasticity Impairs Visual Discrimination Learning in Adenosine A1 Receptor Knock-Out Mice. The Journal Of Neuroscience. 2021. V. 41. N. 21. P. 4631-4640. DOI: 10.1523/JNEUROSCI.3073-20.2021
- Fonar G., Polis B., Sams D.S., Levi A., Malka A., Bal N.V., Maltsev A.V., Elliott E., Samson A.O. Modified Snake α-Neurotoxin Averts β-Amyloid Binding to α7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice. Molecular Neurobiology. 2021. V. 58. N. 5. P. 2322-2341. DOI: 10.1007/s12035-020-02270-0
- Gerasimov E., Erofeev A., Borodinova A.A., Bolshakova A., Balaban P.M., Bezprozvanny I., Vlasova O.L. Optogenetic Activation of Astrocytes-Effects on Neuronal Network Function. International Journal Of Molecular Sciences. 2021. V. 22. N. 17. P. 9613. DOI: 10.3390/ijms22179613
- Gyori J., Kohn A.B., Romanova D., Moroz L.L. ATP signaling in the integrative neural center of Aplysia californica. Scientific Reports. 2021. V. 11. N. 1. P. 5478. DOI: 10.1038/s41598-021-84981-5
- Idzhilova O.S., Roshchin M.V., Smirnova G.R., Malyshev A.Y. Central Targeting of Channelrhodopsin2 by the Motif of Potassium Channel Kv2.1 Can be Altered Due to Overexpression of the Construct. BioNanoScience. 2021. V. 11. N. 2. P. 408-416. DOI: 10.1007/s12668-021-00863-0
- Ivanova V.O., Balaban P.M., Bal N.V. Nitric Oxide Regulates GluA2-Lacking AMPAR Contribution to Synaptic Transmission of CA1 Apical but Not Basal Dendrites. Frontiers In Synaptic Neuroscience. 2021. V. 13. P. 656377. DOI: 10.3389/fnsyn.2021.656377
- Kelmanson I.V., Shokhina A.G., Kotova D.A., Pochechuev M.S., Ivanova V.O., Kostyuk A.I., Panova A.S., Borodinova A.A., Solotenkov M.A., Stepanov E.A., Raevskii R.I., Moshchenko A.A., Pak V.V., Ermakova Y.G., van Belle G.J.C., Tarabykin V., Balaban P.M., Fedotov I.V., Fedotov A.B., Conrad M., Bogeski I., Katschinski D.M., Doeppner T.R., Bahr M., Zheltikov A.M., Belousov V.V., Bilan D.S. In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model. Redox Biology. 2021. V. 48. P. 102178. DOI: 10.1016/j.redox.2021.102178
- Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.V. Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Molecular Biology Reports. 2021. V. 48. N. 5. P. 4549-4561. DOI: 10.1007/s11033-021-06480-0
- Maltsev A.V., Bal N.V., Balaban P.M. Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase. International Journal Of Molecular Sciences. 2021. V. 22. N. 9. P. 4857. DOI: 10.3390/ijms22094857
- Maltsev A.V., Funikov S., Burov A., Spasskaya D., Ignatyuk V., Astakhova O.G., Lyupina Y., Deikin A., Tutyaeva V., Bal N.V., Karpov V., Morozov A. Immunoproteasome Inhibitor ONX-0914 Affects Long-Term Potentiation in Murine Hippocampus. Journal Of Neuroimmune Pharmacology. 2021. V. 16. N. 1. P. 7-11. DOI: 10.1007/s11481-020-09973-0