Лаборатория клеточной нейробиологии обучения

Краткая история и основные направления научной работы лаборатории

Лаборатория была создана в 1989 году на основе группы, проводившей исследования на беспозвоночных животных, входившей в состав лаборатории академика П.В.Симонова.
Основные направления научной работы – клеточные механизмы организации поведения и модификаций поведения в результате обучения, клеточные и молекулярные механизмы памяти. Наряду с традиционными электрофизиологическими методами в лаборатории активно применяются оптические методы регистрации и конфокальная микроскопия. В качестве объекта исследования используются животные с простой нервной системой или срезы мозга позвоночных животных.
Международное сотрудничество – с Йельским Университетом (США) в области оптических методов, с Аризонским Университетом (США) в области анализа нейронных сетей крылоногих моллюсков, с Институтом нейрофизиологии Университета в Бохуме (Германия) и c университетом Коннектикута (США) в области синаптических механизмов пластичности.

Книги

Балабан П.М. Сравнительная физиология памяти. Актуальные проблемы современной физиологии. 2016, изд. Цвет в цифре, Казань 270 стр., стр. 87-101.
Балабан П.М. Принципы организации нервной системы: механизмы обучения и памяти в простых системах, с.12-24. В: Избранные главы фундаментальной и трансляционной медицины / отв. ред. Р.И. Жданов. – Казань: Изд-во Казан. ун-та, 2014. – 592 с. ISBN 987-5-00019-266-5
Тухбатова Г.Р., Гуляев М.В., Свинов М.М., Саложин С.В., Балабан П.М. Применение технологии лентивирусной трансдукции для сравнительного анализа нейропротекторной активности трофических факторов при моделировании острого нарушения мозгового кровообращения в локальных областях мозга. Нейродегенеративные заболевания: от генома до целостного организма // под ред. М.В. Угрюмова. – в 2-х томах - М. : Научный мир, 2014. ISBN 978-591522-400-0
Balaban P.M. (2002) Declarative and procedural memory in animals with simple nervous systems. In: "Psychology at the turn of the millennium, Vol. 1: Cognitive, biological, and health perspectives" (Eds: Lars Bäckman & Claes von Hofsten). Psychology Press, pp. 1-28.
Balaban P.M. Applicability of the reinforcement concept to studies in simple nervous systems. In: Complex Brain Functions. Conceptual Advances in Russian Neuroscience. Eds. A.M.Ivanitsky, P.M.Balaban, Harwood Academic Publishers, 2000, p.201-211.

Список сотрудников

Список публикаций

Статьи

Moroz L.L., Nikitin M.A., Policar P.G., Kohn A.B., Romanova D. Evolution of glutamatergic signaling and synapses. Neuropharmacology. 2021. V. 199. P. 108740. DOI: 10.1016/j.neuropharm.2021.108740
Moroz L.L., Romanova D. Selective Advantages of Synapses in Evolution. Frontiers In Cell And Developmental Biology. 2021. V. 9. P. 726563. DOI: 10.3389/fcell.2021.726563
Moroz L.L., Romanova D., Kohn A.B. Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters. Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences. 2021. V. 376. N. 1821. P. 20190762. DOI: 10.1098/rstb.2019.0762
Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263
Polinski J.M., Zimin A.V., Clark K.F., Kohn A.B., Sadowski N., Timp W., Ptitsyn A., Khanna P., Romanova D., Williams P., Greenwood S.J., Moroz L.L., Walt D.R., Bodnar A.G. The American lobster genome reveals insights on longevity, neural, and immune adaptations. Science Advances. 2021. V. 7. N. 26. eabe8290. DOI: 10.1126/sciadv.abe8290
Romanova D., Varoqueaux F., Daraspe J., Nikitin M.A., Eitel M., Fasshauer D., Moroz L.L. Hidden cell diversity in Placozoa: ultrastructural insights from Hoilungia hongkongensis. Cell And Tissue Research. 2021. V. 385. N. 3. P. 623-637. DOI: 10.1007/s00441-021-03459-y
Roshchina M.A., Smirnov I.V., Isaev A.B., Roshchin M., Borodinova A.A., Aseyev N.A., Balaban P.M. Investigation of ca1 neuronal activity during context fear conditioning with miniature fluorescence microscopes. Opera Medica et Physiologica. 2021. V. 8. N. 3. P. 52-58. DOI: 10.24412/2500-2295-2021-3-52-58
Бородинова А.А., Балабан П.М. Эпигенетическая регуляция как основа долговременных изменений в нервной системе: в поисках механизмов специфичности. Биохимия. 2020. T. 85. № 9. С. 1139-1158. DOI: 10.31857/S0320972520090018
Ермакова Ю.Г., Рощин М.В., Ланин А.А., Балабан П.М., Желтиков А.М., Белоусов В.В., Никитин Е.С. ТЕРМОГЕНЕТИКА КАК НОВОЕ НАПРАВЛЕНИЕ КОНТРОЛЯ АКТИВНОСТИ НЕЙРОННОЙ СЕТИ. ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА. 2020. T. 70. № 1. С. 133-140. DOI: 10.31857/S0044467720010050
Balaban P.M., Borodinova A.A. Neurogenetic Technologies for Research on the Mechanisms Maintaining Memory. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1057-1064. DOI: 10.1007/s11055-020-01005-x
Borodinova A.A., Balaban P.M. Epigenetic Regulation as a Basis for Long-Term Changes in the Nervous System: In Search of Specificity Mechanisms. Biochemistry (Moscow). 2020. V. 85. N. 9. P. 994-1010. DOI: 10.1134/S0006297920090023
Ivanova V.O., Bal N.V., Balaban P.M. Modulation of AMPA receptors by nitric oxide in nerve cells. International Journal of Molecular Sciences. 2020. V. 21. N. 3. DOI: 10.3390/ijms21030981
Malyshev A.Y., Ostrovsky M.A. Experience in the Use of Optogenetic Approaches to Studies of Brain Functions and Prosthetization of Degenerative Retinas. Neuroscience and Behavioral Physiology. 2020. V. 50. N. 8. P. 1065-1071. DOI: 10.1007/s11055-020-01006-w
Moroz L.L., Romanova D., Nikitin M.A., Sohn D., Kohn A.B., Neveu E., Varoqueaux F., Fasshauer D. The diversification and lineage-specific expansion of nitric oxide signaling in Placozoa: insights in the evolution of gaseous transmission. Scientific Reports. 2020. V. 10. N. 1. P. 13020. DOI: 10.1038/s41598-020-69851-w
Moroz L.L., Sohn D., Romanova D., Kohn A.B. Microchemical identification of enantiomers in early-branching animals: Lineage-specific diversification in the usage of D-glutamate and D-aspartate. Biochemical And Biophysical Research Communications. 2020. V. 527. N. 4. P. 947-952. DOI: 10.1016/j.bbrc.2020.04.135
Pfeiffer P., Egorov A.V., Lorenz F., Schleimer J.H., Draguhn A., Schreiber S. Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory. ELife. 2020. V. 9. e49974. DOI: 10.7554/eLife.49974
Romanova D. Glycine as a signaling molecule and chemoattractant in Trichoplax (Placozoa): insights into the early evolution of neurotransmitters. NeuroReport. 2020. V. 31. N. 6. P. 490-497. DOI: 10.1097/WNR.0000000000001436
Romanova D.Y., Smirnov K.S., Nikitin M.A., Kohn A.B., Borman A.I., Malyshev A.Y., Balaban P.M., Moroz L.L. Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals. Biochemical And Biophysical Research Communications. 2020. V. 532. N. 1. P. 120-126. DOI: 10.1016/j.bbrc.2020.08.020
Roshchin M.V., Ierusalimsky V.N., Balaban P.M., Nikitin E.S. Ca(2+)-activated KCa3.1 potassium channels contribute to the slow afterhyperpolarization in L5 neocortical pyramidal neurons. Scientific Reports. 2020. V. 10. N. 1. P. 14484. DOI: 10.1038/s41598-020-71415-x
Балабан П.М., Бородинова А.А. Нейрогенетические технологии исследования механизмов хранения памяти. Рос. физиол. журн . им. И.М. Сеченова. 2019. T. 105. № 11. С. 1392-1405. DOI: 10.1134/S0869813919110025
Borodinova A.A., Kuznetsova M.A., Alekseeva V.S., Balaban P.M. Histone acetylation determines transcription of atypical protein kinases in rat neurons. Scientific Reports. 2019. V. 9. N. 1. P. 4332. DOI: 10.1038/s41598-019-40823-z
Chesnokova E., Zuzina A., Bal N., Vinarskaya A., Roshchin M., Artyuhov A., Dashinimaev E., Aseyev N., Balaban P., Kolosov P. Experiments with Snails Add to Our Knowledge about the Role of aPKC Subfamily Kinases in Learning. International Journal Of Molecular Sciences. 2019. V. 20. N. 9. P. 2117. DOI: 10.3390/ijms20092117
Egorov A.V., Schumacher D., Medert R., Birnbaumer L., Freichel M., Draguhn A. TRPC channels are not required for graded persistent activity in entorhinal cortex neurons. Hippocampus. 2019. V. 29. N. 11. P. 1038-1048. DOI: 10.1002/hipo.23094
Ivanova V.O., Bal N.V., Balaban P.M. Nitric oxide is involved in the mechanism of ampa receptors incorporation into dendrites of pyramidal neurons in hippocampus . // BNA Festival of Neuroscience 2019. 2019. V. 3. PT039 (SP) .
Johansson N., Anikin A., Aseyev N.A. Color sound symbolism in natural languages. Language and Cognition. 2019. V. 12. N. 1. P. 56-83. DOI: 10.1017/langcog.2019.35
Kost L.A., Ivanova V.O., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.M. Red Fluorescent Genetically Encoded Voltage Indicators with Millisecond Responsiveness. Sensors (Basel, Switzerland). 2019. V. 19. N. 13. P. 2982. DOI: 10.3390/s19132982
Maltsev A.V., Bal N.V., Balaban P.M. LTP suppression by protein synthesis inhibitors is NO-dependent. Neuropharmacology. 2019. V. 146. P. 276-288. DOI: 10.1016/j.neuropharm.2018.12.009
Malyshev A.Y., Balaban P.M. More Light on the Brain: 30 Years Later. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 2. P. 159-162. DOI: 10.1007/s11055-019-00728-w
Nikitin E.S., Roschin V.Y., Ierusalimsky V.N., Egorov A.V., Balaban P.M. Optogenetic Stimulation of the Axons of Visual Cortex and Hippocampus Pyramidal Neurons in Living Brain Slices. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 2. P. 227-232. DOI: 10.1007/s11055-019-00719-x
Smirnova G.R., Roshchin M.V., Vinarskaya A.Kh., Kolotova D.Y., Simonova N.A., Balaban P.M., Malyshev A.Y. Use of Anchoring Motifs to Support the Central and Peripheral Locations of Opsins in Optogenetics. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 9. P. 1089-1091. DOI: 10.1007/s11055-019-00843-8
Tyshkovskiy A., Bozaykut P., Borodinova A.A., Gerashchenko M.V., Ables G.P., Garratt M., Khaitovich P., Clish C.B., Miller R.A., Gladyshev V.N. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metabolism. 2019. V. 30. P. 573-593. DOI: 10.1016/j.cmet.2019.06.018
Xu C., Li Q., Efimova O., Petrova M., Vinarskaya A.Kh., Kolosov P.M., Aseyev N.A., Koshkareva K., Ierusalimsky V.N., Balaban P.M., Khaitovich P. Identification of immediate early genes in the nervous system of snail Helix lucorum. eNeuro. 2019. ENEURO.0416-18.2019. DOI: 10.1523/ENEURO.0416-18.2019
Благирев А.А., Чеснокова Е.А., Баль Н.В., Колосов П.М. Транскрипция отдельных нейронов. Журнал высшей нервной деятельности им. И.П. Павлова. 2018. T. 68. № 6. С. 675-702. DOI: 10.1134/S0044467718060047
Dobryakova Y.V., Kasianov A., Zaichenko M.I., Stepanichev M.Y., Chesnokova E.A., Kolosov P.M., Markevich V.A., Bolshakov A.P. Intracerebroventricular administration of <sup>192</sup>IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Frontiers in Molecular Neuroscience. 2018. V. 10. P. 429. DOI: 10.3389/fnmol.2017.00429
Doronin D.A., Barykina N.V., Subach O.M., Sotskov V.P., Plusnin V.V., Ivleva O.A., Isaakova E.A., Varizhuk A.M., Pozmogova G.E., Malyshev A.Y., Piatkevich K.D., Anokhin K.V., Enikolopov G.N., Subach F.V. Genetically encoded calcium indicator with NTnC-like design and enhanced fluorescence contrast and kinetics. BMC Biotechnology. 2018. V. 18. N. 1. P. 10. DOI: 10.1186/s12896-018-0417-2
Ierusalimsky V.N., Balaban P.M. Long-living RNA in the CNS of terrestrial snail. RNA Biology. 2018. V. 15. N. 2. P. 207-213. DOI: 10.1080/15476286.2017.1411460
Muller P., Draguhn A., Egorov A.V. Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons. Journal Of Neurochemistry. 2018. V. 146. N. 4. P. 446-458. DOI: 10.1111/jnc.14479
Roshchin M.V., Ermakova Y.G., Lanin A.A., Chebotarev A.S., Kelmanson I.V., Balaban P.M., Zheltikov A.M., Belousov V.V., Nikitin E.S. Thermogenetic stimulation of single neocortical pyramidal neurons transfected with TRPV1-L channels. Neuroscience Letters. 2018. V. 687. P. 153-157. DOI: 10.1016/j.neulet.2018.09.038
Roshchin M.V., Ierusalimsky N.V., Matlashov M.V., Balaban P.M., Belousov V.V., Kemenes G., Staras K., Nikitin E.S. A BK channel–mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing. Science Advances. 2018. V. 4. N. 7. DOI: 10.1126/SCIADV.AAT1357
Thome C., Roth F.C., Obermayer J., Yanez A., Draguhn A., Egorov A.V. Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons. The Journal Of Physiology. 2018. V. 596. N. 21. P. 5067-5068. DOI: 10.1113/JP276720
Aseyev N.A., Vinarskaya A.K., Roshchin M., Korshunova T.A., Malyshev A.Y., Zuzina A.B., Ierusalimsky V.N., Lemak M.S., Zakharov I.S., Kolosov P.M., Chesnokova E.A., Volkova S., Kasianov A., Uroshlev L., Popova Y., Boyle R.D., Balaban P.M. Adaptive changes in the vestibular system of land snail to a 30-day spaceflight and readaptation on return to earth. Frontiers in Cellular Neuroscience. 2017. V. 11. P. 348. DOI: 10.3389/fncel.2017.00348
Bal N.V., Roshchin M., Salozhin S., Balaban P.M. Nitric Oxide Upregulates Proteasomal Protein Degradation in Neurons. Cellular and Molecular Neurobiology. 2017. V. 37. N. 5. P. 763-769. DOI: 10.1007/s10571-016-0413-9
Bal N.V., Rysakova M.P., Vinarskaya A.K., Ivanova V.O., Zuzina A.B., Balaban P.M. Cued memory reconsolidation in rats requires nitric oxide. European Journal of Neuroscience. 2017. V. 45. N. 5. P. 643-647. DOI: 10.1111/ejn.13503
Barykina N.V., Subach O.M., Piatkevich K.D., Jung E.E., Malyshev A.Y., Bogorodskiy A.O., Borshchevskiy V.I., Varizhuk A.M., Pozmogova G.E., Boyden E.S., Anokhin K.V., Enikolopov G.N., Subach F.V. Green fluorescent genetically encoded calcium indicator based on calmodulin/M13-peptide from fungi. PLoS ONE. 2017. V. 12. N. 8. e0183757. DOI: 10.1371/journal.pone.0183757
Bogodvid T.K., Andrianov V.V., Deryabina I.B., Muranova L.N., Silantyeva D.I., Vinarskaya A., Balaban P.M., Gainutdinov K.L. Responses of withdrawal interneurons to serotonin applications in naïve and learned snails are different. Frontiers in Cellular Neuroscience. 2017. V. 11. P. 403. DOI: 10.3389/fncel.2017.00403
Borodinova A.A., Zuzina A.B., Balaban P.M. Role of atypical protein kinases in maintenance of long-term memory and synaptic plasticity. Biochemistry (Moscow). 2017. V. 82. N. 3. P. 243-256. DOI: 10.1134/S0006297917030026
Chesnokova E.A., Bal N.V., Kolosov P.M. Kinases of eIF2a switch translation of mRNA subset during neuronal plasticity. International Journal of Molecular Sciences. 2017. V. 18. N. 10. E2213. DOI: 10.3390/ijms18102213
Ermakova Y.G., Lanin A.A., Fedotov I.V., Roshchin M., Kelmanson I.V., Kulik D., Bogdanova Y.A., Shokhina A.G., Bilan D.S., Staroverov D.B., Balaban P.M., Fedotov A.B., Sidorov-Biryukov D.A., Nikitin E.S., Zheltikov A.M., Belousov V.V. Thermogenetic neurostimulation with single-cell resolution. Nature Communications. 2017. V. 8. P. 15362. DOI: 10.1038/ncomms15362
Kost L.A., Nikitin E.S., Ivanova V.O., Sung U., Putintseva E.V., Chudakov D.M., Balaban P.M., Lukyanov K.A., Bogdanov A.M. Insertion of the voltage-sensitive domain into circularly permuted red fluorescent protein as a design for genetically encoded voltage sensor. PLoS ONE. 2017. V. 12. N. 9. e0184225. DOI: 10.1371/journal.pone.0184225
Malyshev A.Y., Roshchin M.V., Smirnova G.R., Dolgikh G.A., Balaban P.M., Ostrovsky M.A. Chloride conducting light activated channel GtACR2 can produce both cessation of firing and generation of action potentials in cortical neurons in response to light. Neuroscience Letter. 2017. V. 640. P. 76-80.

Спецвыпуск журнала "Биохимия"

Interplay between neural signaling and metabolic pathways: At the crossroads of brain health and disease