Natalia V. Gulyaeva

Chief of the Department, D.Sc. in Biology, Prof.

molecular basis of disease, animal models, behaviour, glucocorticoid signaling, neurogenesis, neuroinflammation, neuronal plasticity, neuropeptides, stress, dementia, depression, epilepsy, stroke, traumatic brain injury, neurodegenerative diseases

Laboratory of Functional Biochemistry of the Nervous System

E-mail: nata_gul@ihna.ru

Scopus ID: 35571299800
ORCID ID: 0000-0002-5380-7954
Web of Science ResearcherID: R-7959-2016
SPIN code: 4807-1036

Publication list

Papers

Yakovlev A.A., Antonov V., Druzhkova T., Guekht A.B., Gulyaeva N.V. Determination of Cholesterol and Triglyceride Concentrations in Serum Extracellular Vesicles Using Commercial Kits. Biomedical Chemistry: Research and Methods. 2021. V. 4. N. 2. e00148. DOI: 10.18097/BMCRM00148
Brylev L.V., Fominykh V.V., Chernenkaia V., Chernenkiy I., Gorbachev K., Ataulina A., Izvekov A., Monakhov M., Olenichev A., Orlov S., Turin I., Loginov M., Rautbart S., Baymukanov A., Parshikov V., Demeshonok V., Yakovlev A.A., Druzhkova T., Guekht A., Gulyaeva N.V. Stress load and neurodegeneration after gastrostomy tube placement in amyotrophic lateral sclerosis patients. Metabolic Brain Disease. 2021. V. 36. N. 8. P. 2473-2482. DOI: 10.1007/s11011-021-00837-x
Peregud D., Stepanichev M.Yu., Gulyaeva N.V. Expression of the hippocampal PTCH during early abstinence is associated with drinking patterns in a rat model of voluntary alcohol intake. Neuroreport. 2021. V. 32. N. 9. P. 757-761. DOI: 10.1097/WNR.0000000000001646
Stepanichev M.Y., Goryakina T., Manolova A., Lazareva N., Kvichanskii A., Tretyakova L., Volobueva M., Gulyaeva N. Neonatal proinflammatory challenge evokes a microglial response and affects the ratio between subtypes of GABAergic interneurons in the hippocampus of juvenile rats: sex-dependent and sex-independent effects. Brain Structure and Function. 2021. V. 226. N. 2. P. 563-574. DOI: 10.1007/s00429-020-02199-z
Yakovlev A.A., Druzhkova T., Guekht A.B., Gulyaeva N.V. Sensitivity of Extracellular Vesicles from Human Blood Serum to Various Detergents. Biomedical Chemistry: Research and Methods. 2020. V. 3. N. 4. e00143. DOI: 10.18097/BMCRM00143
Kudryashova I., Stepanichev M., Manolova A., Gulyaeva N. Deficit of Long-Term Potentiation Induction, but Not Maintenance, in the Juvenile Hippocampus after Neonatal Proinflammatory Stress. Developmental Neuroscience. 2020. V. 41. N. 5-6. P. 318-326. DOI: 10.1159/000507347
Peregud D.I., Stepanichev M.Yu., Gulyaeva N.V. Drinking Pattern in Intermittent Access Two-Bottle-Choice Paradigm in Male Wistar Rats Is Associated with Exon-Specific BDNF Expression in the Hippocampus During Early Abstinence. Journal Of Molecular Neuroscience. 2020. V. 71. N. 2. P. 262-275. DOI: 10.1007/s12031-020-01645-1
Yakovlev A.A., Druzhkova T.A., Nikolaev R.V., Kuznetsova V.E., Gruzdev S.K., Guekht A.B., Gulyaeva N.V. Elevated Levels of Serum Exosomes in Patients with Major Depressive Disorder. Neurochemical Journal. 2019. V. 36. N. 4. P. 346-352. DOI: 10.1134/S1027813319040046
Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Exosomes secretion and autophagy in long-term protection of neurons from excitotoxic damage. Biomeditsinskaya Khimiya. 2019. V. 65. N. 5. P. 361-365. DOI: 10.18097/PBMC20196505361
Druzhkova T., Pochigaeva K., Yakovlev A.A., Gersamia A., Guekht A., Gulyaeva N.V. Effects of Childhood Trauma on the Biological Correlates of Stress in Men and Women with Borderline Mental Disorders. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 7. P. 916-920. DOI: 10.1007/s11055-019-00819-8
Fominykh V.V., Brylev L.V., Gaskin V., Luzin R., Yakovlev A.A., Komoltsev I., Belousova I., Rosliakova A., Guekht A., Gulyaeva N.V. Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis. Metabolic Brain Disease. 2019. V. 34. N. 5. P. 1473-1485. DOI: 10.1007/s11011-019-00452-x
Gruzdev S.K., Yakovlev A.A., Druzhkova T.A., Guekht A.B., Gulyaeva N.V. The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia. Cellular And Molecular Neurobiology. 2019. V. 39. N. 6. P. 729-750. DOI: 10.1007/s10571-019-00684-6
Kvichanskiy A.A., Volobueva M.N., Spivak Y.S., Tretyakova L.V., Gulyaeva N.V., Bolshakov A.P. Expression of mRNAs for IL-1β, IL-6, IL-10, TNFα, CX3CL1, and TGFβ1 Cytokines in the Brain Tissues: Assessment of Contribution of Blood Cells with and without Perfusion. Biochemistry (Moscow). 2019. V. 84. N. 8. P. 905-910. DOI: 10.1134/S0006297919080066
Martianova E., Aniol V.A., Manolova A.O., Kvichansky A.A., Gulyaeva N.V. Activation of microglia associated with lentiviral transduction: A semiautomated method of assessment. Acta Histochemica. 2019. V. 121. N. 3. P. 368-375. DOI: 10.1016/j.acthis.2019.01.008
Druzhkova T., Pochigaeva K., Yakovlev A.A., Kazimirova E., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers. Metabolic Brain Disease. 2018. V. 34. N. 2. P. 621-629. DOI: 10.1007/s11011-018-0367-3
Fominykh V.V., Vorobyeva A., Onufriev M.V., Brylev L.V., Zakharova M.N., Gulyaeva N.V. Interleukin-6, S-Nitrosothiols, and Neurodegeneration in Different Central Nervous System Demyelinating Disorders: Is There a Relationship?. Journal Of Clinical Neurology (Seoul, Korea). 2018. V. 14. N. 3. P. 327-332. DOI: 10.3988/jcn.2018.14.3.327
Shpak A.A., Guekht A.B., Druzhkova T.A., Kozlova K.I., Gulyaeva N.V. Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract. Current Eye Research. 2018. V. 43. N. 2. P. 224-231. DOI: 10.1080/02713683.2017.1396617
Stepanichev M.Yu., Manolova A.O., Peregud D.I., Onufriev M.V., Freiman S., Aniol V.A., Moiseeva Y.V., Novikova M.R., Lazareva N.A., Gulyaeva N.V. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. 2018. V. 375. P. 49-61. DOI: 10.1016/j.neuroscience.2018.02.007
Grigoryan G.A., Gulyaeva N.V. Modeling Depression in Animals: Behavior as the Basis for the Methodology, Assessment Criteria, and Classification. Neuroscience and Behavioral Physiology. 2017. V. 47. N. 2. P. 204-216. DOI: 10.1007/s11055-016-0386-7
Ivanova O.Y., Dobryakova Y.V., Salozhin S.V., Aniol V.A., Onufriev M.V., Gulyaeva N.V., Markevich V.A. Lentiviral Modulation of Wnt/β-Catenin Signaling Affects In Vivo LTP. Cellular and Molecular Neurobiology. 2017. V. 37. N. 7. P. 1227-1241. DOI: 10.1007/s10571-016-0455-z
Kvichansky A.A., Volobueva M.N., Manolova A.O., Bolshakov A.P., Gulyaeva N.V. Neonatal proinflammatory stress alters the expression of genes of corticosteroid receptors in the rat hippocampus: Septo-temporal differences. Neurochemical Journal. 2017. V. 11. N. 3. P. 255-258. DOI: 10.1134/S1819712417030059
Pochigaeva K., Druzhkova T., Yakovlev A.A., Onufriev M.V., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder. Metabolic Brain Disease. 2017. V. 32. N. 2. P. 577-583. DOI: 10.1007/s11011-017-9952-0
Sokhranyaeva L.S., Aniol V.A., Gulyaeva N.V. Epigenetic modifications of chromatin in epilepsy: A potential mechanism of pharmacoresistance?. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2017. V. 117. N. 9. P. 17-21. DOI: 10.17116/jnevro20171179217-21
Stepanichev M.Yu., Onufriev M., Aniol V.A., Freiman S., Brandstaetter H., Winter S., Lazareva N., Guekht A., Gulyaeva N.V. Effects of cerebrolysin on nerve growth factor system in the aging rat brain. Restorative Neurology and Neuroscience. 2017. V. 35. N. 6. P. 571-581. DOI: 10.3233/RNN-170724
Yakovlev A.A., Lyzhin A.A., Khaspekov L.G., Guekht A.B., Gulyaeva N.V. Peptide drug cortexin inhibits brain caspase-8. Biomeditsinskaya Khimiya. 2017. V. 63. N. 1. P. 27-31. DOI: 10.18097/PBMC20176301027
Aniol V.A., Tishkina A.O., Gulyaeva N.V. Neurogenesis and neuroinflammation: role of Wnt proteins. Nejrokhimija. 2016. V. 33. N. 1. P. 5-11.
Aniol V.A., Tishkina A.O., Salozhin S.V., Kvichanskiy A.A., Gulyaeva N.V. Suppression of postnatal neurogenesis in ra's hippocampus under activity of lentiviral transduction Wnt3. Nejrokhimija. 2016. V. 33. N. 4. P. 301-309.
Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Gekht A.B., Gulyaeva N.V. Activation of caspases in limphocytes of patients with border psychic disorders. Biomeditsynskaja Khimija. 2016. V. 62. N. 1. P. 89-92.
Gulyaeva N.V. Brain plasticity and connectopathy: mechanisms of comorbidity of neurological diseases and depression. Zhurnal Nevropatologii i Psikhiatrii im Korsakova. 2016. V. 1. N. 1. P. 1-100. DOI: 10.17116/jnevro2016116111
Zinchuk M.S., Gekht A.B., Gulyaeva N.V., Avedisova A.S., Akzhigitov R.S., Grishkina M.N. Biological foundations of suicides. Zhurnal Nevrologii i Psikhiatrii im S S Korsakova. 2016. V. 116. N. 8. P. 94-101.
Kudryashova I.V., Gulyaeva N.V. "Unpredictable stress": disambiguity of stress-reactivity when investigating long-term plasticity. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 4. 414–428.
Onufriev M.V., Semenova T.P., Volkova E.P., Sergunkina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal pecularitief of actine expression and CDK5 protein in different brain regions of Yakute gopher (Spermophilus Undulatus). Nejrokhimija. 2016. V. 33. N. 2. P. 103-111.
Onufriev M.V., Semenova T.P., Volkova E.P., Yakovlev A.A., Sergulskaja M.A., Zakharova N.M., Gulyaeva N.V. Features of the expression of CDK1 protein and cyclin B1 in the brain of Yakut gophers (Spermophilus undulatus) at different stages of the hibernation cycle. Nejrokhimija. 2016. V. 33. N. 2. P. 112-121.
Peregud D.I., Panchenko L.F., Gulyaeva N.V. Micro RNA can regulate level of brain neurotrophic factor in rat's frontal cortex under spontaneous cancellation of morphine. Nejrokhimija. 2016. V. 33. N. 4. 323–331.
Peregud D.I., Stepanichev M.Y., Lazareva N.A., Panchenko L.F., Gulyaeva N.V. Influence of single injection of neurotrophic factor into mid tire area on supporting properties of morphine. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. 632–640.
Peregud D.I., Freiman S.V., Tishkina A.O., Sokhranyaeva L.S., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats. Vavilovskij Zhurnal Genetiki i Selektsii. 2016. V. 20. N. 2. P. 191-197.
Stepanichev M.Y., Ivanov A.D., Lazareva N.A., Moiseeva Y.V., Gulyaeva N.V. Neurodegenerative changes caused by the introduction of a fragment (25–35) of a β-amyloid peptide into the hippocampus are associated with activation of NGF signaling. Vestnik RGMU. 2016. V. 1. N. 1. P. 14-19.
Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omeljanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Mojseenok A.G., Gulyaeva N.V. Pantothenic acid derivatives when used with memantine reduce scopolamine-induced amnesia in rats: participation of the redox state of thiols and coenzyme A. Nejrokhimija. 2016. V. 33. N. 2. P. 128-139.
Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshyna I.P., Piskunov A.K., Lazareva N.A., Gulyaeva N.V. Effects of Chronic Combined Stress: Changes in the Behavior of Rats with a Different Reaction to Novelty. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. P. 611-625.
Tishkina A.O., Mart'yanova E.K., Logashina Y.A., Andreev Y.A., Khaibullina S.F., Rizvanov A.A., Gulyaeva N.V., Grishin E.V. Effects of intranasal administration of the peptide antagonist of type I vaniloid receptor (TRPV1) in the rodent central nervous system. Doklady Biological Sciences. 2016. V. 470. N. 1. P. 234-236. DOI: 10.7868/S086956521627030X
Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Stressogenic effects of a single injection of saline: systemic (blood) and central (frontal cortex, dorsal and ventral hippocampus). Najrokhimija. 2016. V. 33. N. 2. P. 122-127.
Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovin A.V., Gulyaeva N.V. Neurotrophic factor of the brain in patients with age-related cataract. Nejrokhimija. 2016. V. 33. N. 3. P. 253-257.
Yakovlev A.A., Gulyaeva N.V. Cortexin's molecular partners in the brain. Nejrokhimija. 2016. V. 33. N. 4. P. 1-6.
Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Caspase activity in peripheral blood mononuclear cells (PBMC) of patients with depression and anxiety of different severity. Biomeditsinskaya Khimiya. 2016. V. 62. N. 5. P. 588-592. DOI: 10.18097/PBMC20166205588
Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage. Biomeditsinskaya Khimiya. 2016. V. 62. N. 6. P. 656-663. DOI: 10.18097/PBMC20166206656
Aniol V.A., Guekht A.B., Gulyaeva N.V. Single seizure and cognition: clinical and translational implications. ARC Journal of Neuroscience. 2016. V. 1. N. 2. P. 4-18. DOI: 10.20431/2456-057x.0102002
Aniol V.A., Tishkina A.O., Gulyaeva N.V. Neurogenesis and neuroinflammation: The role of Wnt proteins. Neurochemical Journal. 2016. V. 10. N. 1. P. 1-6. DOI: 10.1134/S1819712415040030
Aniol V.A., Tishkina A.O., Salozhin S.V., Kvichanskii A.A., Gulyaeva N.V. Suppression of adult hippocampal neurogenesis due to Wnt3a lentivirus transduction. Neurochemical Journal. 2016. V. 10. N. 4. P. 280-287. DOI: 10.1134/S1819712416040024
Bondarenko E.A., Shadrina M.I., Grishkina M.N., Druzhkova T.A., Akzhigitov R.G., Gulyaeva N.V., Guekht A.B., Slominsky P.A. Genetic analysis of BDNF, GNB3, MTHFR, ACE and APOE variants in major and recurrent depressive disorders in Russia. International Journal of Medical Sciences. 2016. V. 13. N. 12. P. 977-983. DOI: 10.7150/ijms.16642
Fominykh V., Onufriev M.V., Vorobyeva A., Brylev L., Yakovlev A.A., Zakharova M.N., Gulyaeva N.V. Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. Journal of Clinical Neuroscience. 2016. V. 28. P. 38-42. DOI: 10.1016/j.jocn.2015.09.017