Natalia V. Gulyaeva
Chief of the Department, D.Sc. in Biology, Prof.
molecular basis of disease, animal models, behaviour, glucocorticoid signaling, neurogenesis, neuroinflammation, neuronal plasticity, neuropeptides, stress, dementia, depression, epilepsy, stroke, traumatic brain injury, neurodegenerative diseases
Laboratory of Functional Biochemistry of the Nervous SystemE-mail: nata_gul@ihna.ru
- Scopus ID
- 35571299800
- ORCID ID
- 0000-0002-5380-7954
- Web of Science ResearcherID
- R-7959-2016
- SPIN code
- 4807-1036
Publication list
Papers
- Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. The stress effects of a single injection of isotonic saline solution: systemic (blood) and central (frontal cortex and dorsal and ventral hippocampus). Neurochemical Journal. 2016. V. 10. N. 2. P. 115-119. DOI: 10.1134/S1819712416020033
- Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Activation of caspases in lymphocytes of patients with borderline personality disorders. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2016. V. 10. N. 3. P. 246-250. DOI: 10.1134/S1990750816030021
- Gulyaeva N.V. Studies on stress-induced modulation of long term potentiation in rodent hippocampus: What can we learn about pathogenesis of depression?. Translational Brain Rhythmicity. 2016. V. 1. P. 1. DOI: 10.15761/TBR.1000107
- Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal changes in actin and Cdk5 expression in different brain regions of the Yakut ground squirrel (Spermophilus undulatus). Neurochemical Journal. 2016. V. 10. N. 2. P. 98-105. DOI: 10.1134/S1819712416020070
- Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. The characteristics of the expression of the Cdk1 and Cyclin B1 Proteins in the brain of the Yakut ground squirrel (Spermophilus undulatus) at different stages of the hibernation cycle. Neurochemical Journal. 2016. V. 10. N. 2. P. 106-114. DOI: 10.1134/S1819712416020082
- Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cellular and Molecular Neurobiology. 2016. V. 36. N. 6. P. 839-849. DOI: 10.1007/s10571-015-0267-6
- Piskunov A., Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I., Gulyaeva N.V. Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metabolic Brain Disease. 2016. V. 31. N. 2. P. 445-454. DOI: 10.1007/s11011-015-9785-7
- Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033
- Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033
- Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omelyanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Moiseenok A.G., Gulyaeva N.V. Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A. Neurochemical Journal. 2016. V. 10. N. 2. P. 120-130. DOI: 10.1134/S1819712416020094
- Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031
- Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031
- Tishkina A.O., Stepanichev M.Y., Kudryashova I.V., Freiman S., Onufriev M.V., Lazareva N.A., Gulyaeva N.V. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behavioural Brain Research. 2016. V. 304. P. 1-10. DOI: 10.1016/j.bbr.2016.02.001
- Aniol V.A., Gulyaeva N.V. Changes in postnatal neurogenesis in hippocampus terminative zone in humans after depressive spectrum disorders. Nejrokhimija. 2015. V. 32. N. 1. P. 13-18.
- Balaban P.M., Gulyaeva N.V. Neurophilosophy. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2015. V. 65. N. 4. P. 498-502. DOI: 10.7868/S0044467715040036
- Grigoryan G.A., Gulyaeva N.V. Simulation of animal depression: behavior as basis for methodology, estimation crtiteria and classification. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2015. V. 55. N. 6. P. 643-660.
- Druzhkova T.A., Pochigaeva K.I., Gekht A.B., Gulyaeva N.V. Estimate of free cortizole in saliva: relationship with cortizole in blood serum in patients with depressive disorders. Nejrokhimija. 2015. V. 32. N. 4. P. 334-338. DOI: 10.17116/jnevro2016116111
- Ivanova-Dyatlova A.Y., Aniol V.A., Gulyaeva N.V. Ultra-low doses of tetrahydrocannabinol contribute to the survival of newly-born cells in the dentate gyrus of adult rats. Nejrokhimija. 2015. V. 32. N. 3. P. 265-270.
- Komoltsev I.G., Levshyna I.P., Novikova M.R., Stepanichev M.Y., Tishkina A.O., Gulyaeva N.V. Changes in brain cortex after dozing head inhury in rats with different age. Morphologija. 2015. V. 148. N. 5. P. 14-20.
- Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Martianov E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. Expression of TrkA and TrkB neurotrophins high affinity receptors in rat hippocampus after intracerebroventricular administration of βA (25-35). Nejrokhimija. 2015. V. 32. N. 1. P. 57-63.
- Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovin A.V., Gulyaeva N.V. Ciliary neurotrophic factor in patients with age-related cataract. Nejrokhimija. 2015. V. 32. N. 4. 330–333.
- Yakovlev A.A., Gulyaeva N.V. Preconditioning brain cells for pathological effects: the involvement of proteases. Biokhimija. 2015. V. 80. N. 2. P. 204-220.
- Aniol V.A., Gulyaeva N.V. Changes in adult neurogenesis in the hippocampus during depressive disorders in humans. Neurochemical Journal. 2015. V. 9. N. 1. P. 8-12. DOI: 10.1134/S181971241501002X
- Druzhkova T.A., Pochigaeva K.I., Guekht A.B., Gulyaeva N.V. Free cortisol assessment in saliva: Saliva-to-serum ratio in depressed patients. Neurochemical Journal. 2015. V. 9. N. 4. P. 315-318. DOI: 10.1134/S1819712415040078
- Dygalo N.N., Stepanichev M.Y., Gulyaeva N.V., Shishkina G.T. Expression of genes in the brain associated with depression. Russian Journal of Genetics: Applied Research. 2015. V. 5. N. 6. P. 582-588. DOI: 10.1134/S2079059715060027
- Freiman S.V., Onufriev M.V., Druzhkova T.A., Yakovlev A.A., Pochigaeva K.I., Chepelev A.V., Grishkina M.N., Gudkova A.A., Gekht A.B., Gulyaeva N.V. The change in blood glucose level after a moderate stress as a parameter of stress reactivity in anxiety and depression: A pilot translational study. Neurochemical Journal. 2015. V. 9. N. 2. P. 146-148. DOI: 10.1134/S1819712415020051
- Gulyaeva N.V. Brain ischemia, endoplasmic reticulum stress, and astroglial activation: New insights. Journal of Neurochemistry. 2015. V. 132. N. 3. P. 263-265. DOI: 10.1111/jnc.13016
- Ivanova-Dyatlova A.Y., Aniol V.A., Gulyaeva N.V. Ultra-low doses of tetrahydrocannabinol contribute to the survival of newly-born cells in the dentate gyrus of adult rats. Neurochemical Journal. 2015. V. 9. N. 3. P. 232-236. DOI: 10.1134/S1819712415030046
- Shpak A.A., Gekht A.B., Druzhkova T.A., Kozlova K.I., Golovina A.V., Gulyaeva N.V. Ciliary neurotrophic factor in patients with age-related cataracts. Neurochemical Journal. 2015. V. 9. N. 4. P. 311-314.
- Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Mart'yanova E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35). Neurochemical Journal. 2015. V. 9. N. 1. P. 47-53. DOI: 10.1134/S1819712415010110
- Uzakov S.S., Ivanov A.D., Salozhin S.V., Markevich V.A., Gulyaeva N.V. Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus. Brain Research. 2015. V. 1624. P. 398-404. DOI: 10.1016/j.brainres.2015.07.051
- Yakovlev A.A., Gulyaeva N.V. Possible role of proteases in preconditioning of brain cells to pathological conditions. Biochemistry (Moscow). 2015. V. 80. N. 2. P. 163-171. DOI: 10.1134/S0006297915020030
- Peregud D.I., Panchenko L.F., Gulyaeva N.V. Elevation of BDNF Exon I-Specific Transcripts in the Frontal Cortex and Midbrain of Rat During Spontaneous Morphine Withdrawal is Accompanied by Enhanced pCreb1 Occupancy at the Corresponding Promoter. Neurochemical Research. 2014. V. 40. N. 1. P. 130-138. DOI: 10.1007/s11064-014-1476-y
- Stepanichev M.Y., Lazareva N.A., Tukhbatova G.R., Salozhin S., Gulyaeva N.V. Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction. Behavioural Brain Research. 2014. V. 259. P. 152-157. DOI: 10.1016/j.bbr.2013.11.013
- Aniol V.A., Ivanova-Dyatlova A.Y., Keren O., Guekht A.B., Sarne Y., Gulyaeva N.V. A single pentylenetetrazole-induced clonic-tonic seizure episode is accompanied by a slowly developing cognitive decline in rats. Epilepsy and Behavior. 2013. V. 26. N. 2. P. 196-202. DOI: 10.1016/j.yebeh.2012.12.006
- Gulyaeva N.V., Stepanichev M.Y. The anti-AD cookbook: A new recipe. Journal of Neurochemistry. 2013. V. 125. N. 1. P. 4-6. DOI: 10.1111/jnc.12138
- Stepanichev M.Yu., Onufriev M.V., Piskunov A.K., Moiseeva Y.V., Lazareva N.A., Moiseenok A.G., Gusev P.V., Gulyaeva N.V. The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress. Neurochemical Journal. 2013. V. 7. N. 2. P. 144-149. DOI: 10.1134/S1819712413020062
- Gulyaeva N.V. Neuroplasticity and epilepsy: modern conceptions and mechanisms of comorhybridity of epilepsy and depression. Zhurnal Nevrologii i Psikhiatrii im S. 2012. V. 52. N. 12. ???. DOI: 10.17116/jnevro2015115112
- Markevich V.A., Sapozhin S.V., Gulyaeva N.V. Involvement of WNT signalling in hippocampal plasticity. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2012. V. 98. N. 12. P. 1460-1470.
- Brylev L.V., Zakharova M.N., Zavalishin I.A., Gulyaeva N.V. Disruption of blood-brain barrier in amyotrophic lateral sclerosis: An update. Neurochemical Journal. 2012. V. 6. N. 1. P. 64-70. DOI: 10.1134/S1819712411040064
- Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Bull Exp Biol Med.. 2012. V. 153. N. 6. P. 835-838.
- Tishkina A.O., Rukhlenko A., Stepanichev M.Yu., Levshina I., Pasikova N.V., Onufriev M.V., Moiseeva Y.V., Piskunov A., Gulyaeva N.V. Region-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metabolic Brain Disease. 2012. V. 27. N. 4. P. 431-41. DOI: 10.1007/s11011-012-9328-4
- Aniol V.A., Stepanichev M.Y., Lazareva N.A., Gulyaeva N.V. An early decrease in cell proliferation after pentylenetetrazole-induced seizures. Epilepsy and Behavior. 2011. V. 22. N. 3. P. 433-441. DOI: 10.1016/j.yebeh.2011.08.002
- Yakovlev A.A., Gulyaeva N.V. Pleiotropic functions of brain proteinases: Methodological considerations and search for caspase substrates. Biochemistry (Moscow). 2011. V. 76. N. 10. P. 1079-1086. DOI: 10.1134/S0006297911100014
- Sarkisova K.Y., Novikova M.R., Zaichenko M.I., Paramokhin M.L., Gadalin Y.S., Gulyaeva N.V. Remote control of the goal-directed behavior of freely moving rats by telestimulation of the rewarding brain structures. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2010. V. 60. N. 2. P. 236-246.
- Antipova T.A., Sapozhnikova D.S., Stepanichev M.Y., Onufriev M.V., Gulyaeva N.V., Seredenin S.B. Effects of selective anxiolytic afobazole on active caspase-3. Bulletin of Experimental Biology and Medicine. 2010. V. 149. N. 2. P. 201-203. DOI: 10.1007/s10517-010-0907-2
- Gulyaeva N.V., Stepanichev M.Y. AΒ(25-35) as proxyholder for amyloidogenic peptides: In vivo evidence. Experimental Neurology. 2010. V. 222. N. 1. P. 6-9. DOI: 10.1016/j.expneurol.2009.12.019
- Gulyaeva N.V., Stepanichev M.Y. AΒ(25-35) as proxyholder for amyloidogenic peptides: In vivo evidence. Experimental Neurology. 2010. V. 222. N. 1. P. 6-9. DOI: 10.1016/j.expneurol.2009.12.019
- Pavlova T.V., Fesenko G.N., Gekht A.B., Gulyaeva N.V., Kovalzon V.M. Convulsive activity in the electroencephalogram in rats sensitive and tolerant to pentylenetetrazol kindling. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 239-244. DOI: 10.1007/s11055-010-9249-9
- Pavlova T.V., Stepanichev M.Y., Gekht A.B., Gulyaeva N.V. Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 5. P. 501-506. DOI: 10.1007/s11055-010-9288-2