Журнальный клуб 31.05.2012
31 мая в 15:00 в конференц-зале ИВНД и НФ состоится заседание Журнального клуба. Доклад подготовит Ольга Гурская на основе статьи: Synergistic Actions of Metabotropic Acetylcholine and Glutamate Receptors on the Excitability of Hippocampal CA1 Pyramidal Neurons. Jin-Yong Park and Nelson Spruston //The Journal of Neuroscience,May 2,2012, 32(18):6081–6091
A variety of neurotransmitters are responsible for regulating neural activity during different behavioral states. Unique responses to combinations of neurotransmitters provide a powerful mechanism by which neural networks could be differentially activated during a broad range of behaviors. Here, we show, using whole-cell recordings in rat hippocampal slices, that group I metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) synergistically increase the excitability of hippocampal CA1 pyramidal neurons by converting the post-burst after hyperpolarization to an after depolarization via a rapidly reversible upregulation of Cav2.3 R-type calcium channels. Coactivation of mAChRs and mGluRs also induced a long-lasting enhancement of the responses mediated by each receptor type. These results suggest that cooperative signaling via mAChRs and group I mGluRs could provide a mechanism by which cognitive processes may be modulated by conjoint activation of two separate neurotransmitter systems.