В среду 4 мая в 15:00 в конференц-зале ИВНД и НФ состоится очередное заседание Журнального клуба. Доклад подготовит Ольга Гурская на основе статьи: Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β, NATURE NEUROSCIENCE published online 27 March 2011.
Amyloid-Aβ1–42(Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer’s disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3b is an important mediator of this effect in rats and mice.