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Laboratory of Molecular Neurobiology

The Laboratory of Molecular Neurobiology appeared in 2007 as a group for the study of molecular neurobiology inside the laboratory of cellular neuroscience training. But already in 2010, a separate laboratory was formed under the leadership of Sergey Vladimirovich Salozhin. At this time, the laboratory mastered the basic methods of creating lentiviral vectors and packaging of lentiviral particles, as well as the creation of adeno-associated viruses and the technology of their concentration. In 2015, the laboratory was headed by Alexey Petrovich Bolshakov, and now the work is carried out in several priority areas:

  • Research of the epigenetic regulation of the processes of memory formation and storage. -Research of neuroinflammation.
  • Studies of gene expression during plastic rearrangements in the brain are normal and in models of CNS pathologies.
  • Investigations of the role of non-coding RNA in the functioning of CNS cells.
  • Electrophysiological and behavioral studies of the processes occurring in the brain of experimental animals with the spreading depression (one of the pathophysiological mechanisms of migraine) and the epileptiform activity of various genesis.
  • Optimization of methods for assembling various viral constructions (lentiviruses, adeno-associated viruses), packaging of viruses for use in laboratory and interlaboratory projects.

To perform work on projects in the laboratory, a wide range of methods is actively used: standard molecular biological (PCR, real-time PCR, RNA and DNA isolation, electrophoresis, cloning, etc.), chromatin precipitation (ChIP-pcr), western blot; work with primary cultures of neurons and cell lines PC12, HEK293; work with bacterial strains (transformation, plasmid production, purification); assembly of viral constructs (lentiviruses, adeno-associated viruses) for overexpression of target products in vitro and in vivo; work with animals (injection of viruses into various areas of the brain, in vivo electrophysiology, behavioral testing of emotional and cognitive disorders in CNS pathology, neuropharmacological methods; experimental modeling of epilepsy); immunohistochemistry, immunocytochemistry.

Employee list

Publication list

  1. Karan A.A., Spivak Y.S., Gerasimov K.A., Suleymanova E.M., Volobueva M.N., Kvichanskiy A.A., Vinogradova L.V., Bolshakov A.P. CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex. Molecular Neurobiology. 2021. DOI: 10.1007/s12035-021-02395-w.
  2. Kolesov D.V., Ivanova V.O., Sokolinskaya E.L., Kost L.A., Balaban P.M., Lukyanov K.A., Nikitin E.S., Bogdanov A.V. Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity. Molecular Biology Reports. 2021. V. 48. N. 5. P. 4549-4561. DOI: 10.1007/s11033-021-06480-0.
  3. Mikhailova M.M., Volobueva M.N., Panteleyev A.A. Mechanisms driving the initiation and direction of endothelial sprouting in organotypic co-culture of aorta and spinal cord tissues. Cell Biochemistry And Function. 2021. DOI: 10.1002/cbf.3634.
  4. Nikitin E.S., Vinogradova L.V. Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion On Therapeutic Targets. 2021. V. 6. P. 1-13. DOI: 10.1080/14728222.2021.1908263.
  5. Stepanichev M.Y., Goryakina T., Manolova A., Lazareva N., Kvichanskii A., Tretyakova L., Volobueva M., Gulyaeva N. Neonatal proinflammatory challenge evokes a microglial response and affects the ratio between subtypes of GABAergic interneurons in the hippocampus of juvenile rats: sex-dependent and sex-independent effects. Brain Structure and Function. 2021. V. 226. N. 2. P. 563-574. DOI: 10.1007/s00429-020-02199-z.
  6. Bolshakov A.P., Stepanichev M.Y., Dobryakova Y.V., Spivak Y.S., Markevich V.A. Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience. Toxins. 2020. V. 12. N. 9. P. 546. DOI: 10.3390/toxins12090546.
  7. Vinogradova L.V., Rysakova M.P., Pavlova I.V. Small damage of brain parenchyma reliably triggers spreading depolarization. Neurological Research. 2020. V. 42. N. 1. P. 76-82. DOI: 10.1080/01616412.2019.1709745.
  8. Vinogradova L.V., Suleymanova E.M., Medvedeva T.M. Transient loss of interhemispheric functional connectivity following unilateral cortical spreading depression in awake rats. Cephalalgia. 2020. V. 8. P. 333102420970172. DOI: 10.1177/0333102420970172.
  9. Borodinova A.A., Kuznetsova M.A., Alekseeva V.S., Balaban P.M. Histone acetylation determines transcription of atypical protein kinases in rat neurons. Scientific Reports. 2019. V. 9. N. 1. P. 4332. DOI: 10.1038/s41598-019-40823-z.
  10. Kvichanskiy A.A., Volobueva M.N., Spivak Y.S., Tretyakova L.V., Gulyaeva N.V., Bolshakov A.P. Expression of mRNAs for IL-1β, IL-6, IL-10, TNFα, CX3CL1, and TGFβ1 Cytokines in the Brain Tissues: Assessment of Contribution of Blood Cells with and without Perfusion. Biochemistry (Moscow). 2019. V. 84. N. 8. P. 905-910. DOI: 10.1134/S0006297919080066.
  11. Suleymanova E.M., Borisova M.A., Vinogradova L.V. Early endocannabinoid system activation attenuates behavioral impairments induced by initial impact but does not prevent epileptogenesis in lithium-pilocarpine status epilepticus model. Epilepsy &amp; Behavior. 2019. V. 92. P. 71-78. DOI: 10.1016/j.yebeh.2018.12.001.
  12. Dobryakova Y.V., Kasianov A., Zaichenko M.I., Stepanichev M.Y., Chesnokova E.A., Kolosov P.M., Markevich V.A., Bolshakov A.P. Intracerebroventricular administration of <sup>192</sup>IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Frontiers in Molecular Neuroscience. 2018. V. 10. P. 429. DOI: 10.3389/fnmol.2017.00429.
  13. Sarkisova K.Y., Gabova A.V. Maternal care exerts disease-modifying effects on genetic absence epilepsy and comorbid depression. Genes, Brain and Behavior. 2018. V. 17. N. 7. e12477. DOI: 10.1111/gbb.12477.
  14. Shaydurov V.A., Kasianov A., Bolshakov A.P. Analysis of Housekeeping Genes for Accurate Normalization of qPCR Data During Early Postnatal Brain Development. Journal of Molecular Neuroscience. 2018. V. 64. N. 3. P. 431-439. DOI: 10.1007/s12031-018-1037-y.
  15. Vinogradova L.V. Initiation of spreading depression by synaptic and network hyperactivity: Insights into trigger mechanisms of migraine aura. Cephalalgia. 2018. V. 38. N. 6. P. 1177-1187. DOI: 10.1177/0333102417724151.
  16. Vinogradova L.V., Shatskova A.B. Localizing and lateralizing values of postictal behavioral impairments in epileptic rats. Epilepsy &amp; Behavior. 2018. V. 87. P. 195-199. DOI: 10.1016/j.yebeh.2018.07.016.
  17. Borodinova A.A., Zuzina A.B., Balaban P.M. Role of atypical protein kinases in maintenance of long-term memory and synaptic plasticity. Biochemistry (Moscow). 2017. V. 82. N. 3. P. 243-256. DOI: 10.1134/S0006297917030026.
  18. Kvichansky A.A., Volobueva M.N., Manolova A.O., Bolshakov A.P., Gulyaeva N.V. Neonatal proinflammatory stress alters the expression of genes of corticosteroid receptors in the rat hippocampus: Septo-temporal differences. Neurochemical Journal. 2017. V. 11. N. 3. P. 255-258. DOI: 10.1134/S1819712417030059.
  19. Nikitin E.S., Bal N.V., Malyshev A.Y., Ierusalimsky V.N., Spivak Y.S., Balaban P.M., Volgushev M.A. Encoding of high frequencies improves with maturation of action potential generation in cultured neocortical neurons. Frontiers in Cellular Neuroscience. 2017. V. 11. P. 28. DOI: 10.3389/fncel.2017.00028.
  20. Rozov A.V., Valiullina F.F., Bolshakov A.P. Mechanisms of long-term plasticity of hippocampal GABAergic synapses. Biochemistry (Moscow). 2017. V. 82. N. 3. P. 257-263. DOI: 10.1134/S0006297917030038.
  21. Sarkisova K.Y., Gabova A.V., Kulikov M.A., Fedosova E.A., Shatskova A.B., Morosov A.A. Rearing by foster Wistar mother with high level of maternal care counteracts the development of genetic absence epilepsy and comorbid depression in WAG/Rij rats. Doklady Biological Sciences. 2017. V. 473. N. 1. P. 39-42. DOI: 10.1134/S0012496617020077.
  22. Vinogradova L.V. Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features. Epilepsy and Behavior. 2017. V. 71. P. 142-153. DOI: 10.1016/j.yebeh.2015.06.014.
  23. Borodinova A.A., Salozhin S.V. Diversity of proBDNF and mBDNF functions in the central nervous system. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2016. V. 66. N. 1. P. 3-23. DOI: 10.7868/S0044467716010044.
  24. Borodinova A.A., Salozhin S.V. Diversity of proBDNF and mBDNF functions in the central nervous system. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2016. V. 66. N. 1. P. 3-23. DOI: 10.7868/S0044467716010044.
  25. Midzyanovskaya I.S., Biryukova L.M., Shatskova A.B., van Luijtelaar G., Tuomisto L.M. H1 histamine receptor densities are increased in brain regions of rats with genetically generalized epilepsies. Epilepsy Research. 2016. V. 127. P. 135-140. DOI: 10.1016/j.eplepsyres.2016.08.029.
  26. Suleymanova E.M., Gulyaev M.V., Abbasova K.R. Structural alterations in the rat brain and behavioral impairment after status epilepticus: An MRI study. Neuroscience. 2016. V. 315. P. 79-90. DOI: 10.1016/j.neuroscience.2015.11.061.
  27. Suleymanova E.M., Shangaraeva V.A., VanRijn C.M., Vinogradova L.V. The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats. Neuroscience. 2016. V. 334. P. 191-200. DOI: 10.1016/j.neuroscience.2016.08.004.
  28. Sysoeva M.V., Vinogradova L.V., Kuznetsova M.A., Sysoev I.V., VanRijn C.M. Changes in corticocortical and corticohippocampal network during absence seizures in WAG/Rij rats revealed with time varying Granger causality. Epilepsy and Behavior. 2016. V. 64. P. 44-50. DOI: 10.1016/j.yebeh.2016.08.009.
  29. Vinogradova L.V., Grinenko O.A. Ictal electrographic pattern of focal subcortical seizures induced by sound in rats. Brain Research. 2016. V. 1635. P. 161-168. DOI: 10.1016/j.brainres.2016.01.027.
  30. Volkova E.P., Rozov A.V., Nadareishvili G.G., Bolshakov A.P. Corticosterone Induces Rapid Increase in the Amplitude of Inhibitory Response in Hippocampal Synapses with Asynchronous GABA Release. Bulletin of Experimental Biology and Medicine. 2016. V. 160. N. 5. P. 628-631. DOI: 10.1007/s10517-016-3234-4.
  31. Ierusalimsky V.N., Borodinova A.A., Balaban P.M. Localization of the atypical protein kinase Cζ in the Nervous System of the terrestrial snail Helix. Neyrokhimiya. 2015. V. 32. N. 4. P. 295-301. DOI: 10.7868/S1027813315040093.
  32. Dolgikh D.A., Malyshev A.Y., Salozhin S.V., Nekrasova O.V., Petrovskaya L.E., Roshchin M.V., Borodinova A.A., Feldman T.B., Balaban P.M., Kirpichnikov M.P., Ostrovsky M.A. Anion-selective channelrhodopsin expressed in neuronal cell culture and in vivo in murine brain: Light-induced inhibition of generation of action potentials. Doklady Biochemistry and Biophysics. 2015. V. 465. N. 1. P. 424-427. DOI: 10.1134/S160767291506023X.
  33. Matlashov M.E., Bogdanova Y.A., Ermakova G.V., Mishina N.M., Ermakova Y.G., Nikitin E.S., Balaban P.M., Okabe S., Lukyanov S.A., Enikolopov G., Zaraisky A.G., Belousov V.V. Fluorescent ratiometric pH indicator SypHer2: Applications in neuroscience and regenerative biology. Biochimica et Biophysica Acta - General Subjects. 2015. V. 1850. N. 11. P. 2318-2328. DOI: 10.1016/j.bbagen.2015.08.002.
  34. Vinogradova L.V. Comparative potency of sensory-induced brainstem activation to trigger spreading depression and seizures in the cortex of awake rats: Implications for the pathophysiology of migraine aura. Cephalalgia. 2015. V. 35. N. 11. P. 979-986. DOI: 10.1177/0333102414565672.
  35. Vinogradova L.V., VanRijn C.M. Long-term disease-modifying effect of the endocannabinoid agonist WIN55,212-2 in a rat model of audiogenic epilepsy. Pharmacological Reports. 2015. V. 67. N. 3. P. 501-503. DOI: 10.1016/j.pharep.2014.12.002.
  36. Suleymanova E.M., Gulyaev M., Chepurnova N. Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain. Epilepsy Research. 2014. V. 108. N. 2. P. 223-231. DOI: 10.1016/j.eplepsyres.2013.11.018.
  37. Borodinova A.A., Abramochkin D.V., Sukhova G.S. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental Physiology. 2013. V. 98. N. 12. P. 1659-1667. DOI: 10.1113/expphysiol.2013.074989.
  38. Samotaeva I.S., Tillmanns N., VanLuijtelaar G., Vinogradova L.V. Intracortical microinjections may cause spreading depression and suppress absence seizures. Neuroscience. 2013. V. 230. P. 50-55. DOI: 10.1016/j.neuroscience.2012.11.013.
  39. Suntsova M., Gogvadze E.V., Salozhin S., Gaifullin N., Eroshkin F., Dmitriev S.E., Martynova N., Kulikov K., Malakhova G., Tukhbatova G., Bolshakov A.P., Ghilarov D., Garazha A., Aliper A., Cantor C.R., Solokhin Y., Roumiantsev S., Balaban P.M., Zhavoronkov A., Buzdin A. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. Proceedings of the National Academy of Sciences of the United States of America. 2013. V. 110. N. 48. P. 19472-19477. DOI: 10.1073/pnas.1318172110.
  40. Suntsova M., Gogvadze E.V., Salozhin S., Gaifullin N., Eroshkin F., Dmitriev S.E., Martynova O.V., Kulikov M.A., Malakhova G., Tukhbatova G., Bolshakov A.P., Ghilarov D., Garazha A., Aliper A., Cantor C.R., Solokhin Y., Roumiantsev S., Balaban P.M., Zhavoronkov A., Buzdin A. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. Proceedings of the National Academy of Sciences of the United States of America. 2013. V. 110. N. 48. P. 19472-19477. DOI: 10.1073/pnas.1318172110.
  41. Abramochkin D.V., Borodinova A.A., Rosenshtraukh L.V. Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 2012. V. 182. N. 1. P. 101-108. DOI: 10.1007/s00360-011-0602-2.
  42. Abramochkin D.V., Borodinova A.A., Rosenshtraukh L.V., Nikolsky E.E. Both neuronal and non-neuronal acetylcholine take part in non-quantal acetylcholine release in the rat atrium. Life Sciences. 2012. V. 91. N. 21-22. P. 1023-1026. DOI: 10.1016/j.lfs.2012.03.031.
  43. Samotaeva I.S., Biryukova L.M., Midzyanovskaya I.S., Kuznetsova M.A., Bazyan A.S., Tuomisto L. Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats. Epilepsy Research. 2012. V. 101. N. 1-2. P. 148-56. DOI: 10.1016/j.eplepsyres.2012.03.016.
  44. Vinogradova L.V., Shatskova A.B. Lateral asymmetry of early seizure manifestations in experimental generalized epilepsy. Neuroscience. 2012. V. 213. P. 133-143. DOI: 10.1016/j.neuroscience.2012.03.060.
  45. VanRijn C.M., Perescis M.F., Vinogradova L.V., VanLuijtelaar G. Endocannabinoid system protects against cryptogenic seizures. Pharmacological Reports. 2011. V. 63. N. 1. P. 165-168.
  46. Vinogradova L.V., Shatskova A.B., VanRijn C.M. Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy. Epilepsy Research. 2011. V. 96. N. 3. P. 250-256. DOI: 10.1016/j.eplepsyres.2011.06.007.
  47. Abramochkin D.V., Nurullin L.F., Borodinova A.A., Tarasova N.V., Sukhova G.S., Nikolsky E.E., Rosenshtraukh L.V. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats: Experimental Physiology-Research Paper. Experimental Physiology. 2010. V. 95. N. 2. P. 265-273. DOI: 10.1113/expphysiol.2009.050302.
  48. Brustovetsky T., Bolshakov A.P., Brustovetsky N. Calpain activation and Na<sup>+</sup>/Ca<sup>2+</sup> exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate. Journal of Neuroscience Research. 2010. V. 88. N. 6. P. 1317-1328. DOI: 10.1002/jnr.22295.
  49. Helbig I., Sammler E., Eliava M., Bolshakov A.P., Rozov A., Bruzzone R., Monyer H., Hormuzdi S.G. In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse. Molecular and Cellular Neuroscience. 2010. V. 45. N. 1. P. 47-58. DOI: 10.1016/j.mcn.2010.05.008.
  50. Salozhin S.V., Bolshakov A.P. Transfection of nerve cells. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 3. P. 269-277. DOI: 10.1007/s11055-010-9254-z.
  51. Vinogradova L.V. Interhemispheric difference in susceptibility to epileptogenesis: Evidence from the audiogenic kindling model in Wistar rats. Brain Research. 2010. V. 1329. P. 175-181. DOI: 10.1016/j.brainres.2010.03.037.
  52. Salozhin S.V., Bolshakov A.P. Transfection of the nervous system cells. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2009. V. 59. N. 1. P. 3-14.
  53. Vinogradova L.V., Kuznetsova M.A., Coenen A.M. Unilateral cortical spreading depression induced by sound in rats. Brain Research. 2009. V. 1286. P. 201-207. DOI: 10.1016/j.brainres.2009.06.047.
  54. Bolshakov A.P., Mikhailova M.M., Szabadkai G., Pinelis V.G., Brustovetsky N., Rizzuto R., Khodorov B.I. Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca<sup>2+</sup> deregulation. Cell Calcium. 2008. V. 43. N. 6. P. 602-614. DOI: 10.1016/j.ceca.2007.10.005.
  55. Vinogradova L.V. Audiogenic kindling in Wistar and WAG/Rij rats: Kindling-prone and kindling-resistant subpopulations. Epilepsia. 2008. V. 49. N. 10. P. 1665-1674. DOI: 10.1111/j.1528-1167.2008.01617.x.
  56. Vinogradova L.V., VanRijn C.M. Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model. Epilepsia. 2008. V. 49. N. 7. P. 1160-1168. DOI: 10.1111/j.1528-1167.2008.01594.x.
  57. Souslova E.A., Belousov V.V., Lock J.G., Stromblad S., Kasparov S., Bolshakov A.P., Pinelis V.G., Labas Y.A., Lukyanov S., Mayr L.M., Chudakov D.M. Single fluorescent protein-based Ca<sup>2+</sup> sensors with increased dynamic range. BMC Biotechnology. 2007. V. 7. P. 37. DOI: 10.1186/1472-6750-7-37.
  58. Vinogradova L.V., Shatskova A.B., Tuomisto L. Histaminergic modulation of acoustically induced running behavior in rats. Brain Research. 2007. V. 1148. N. 1. P. 198-204. DOI: 10.1016/j.brainres.2007.02.017.
  59. Koronovsky A.A., Kuznetsova G.D., Midzyanovskaya I.S., Sitnikova E.Y., Trubetskov D.I., Khramov A.E. Patterns of intermittent behavior in spontaneous non-convulsive convulsive activity in rats. Doklady Akademii Nauk. 2006. V. 409. N. 2. P. 274-276.
  60. Shalbuyeva N., Brustovetsky T., Bolshakov A.P., Brustovetsky N. Calcium-dependent spontaneously reversible remodeling of brain mitochondria. Journal of Biological Chemistry. 2006. V. 281. N. 49. P. 37547-37558. DOI: 10.1074/jbc.M607263200.
  61. Surin A.M., Bolshakov A.P., Mikhailova M.M., Sorokina E.G., Senilova Y.E., Pinelis V.G., Khodorov B.I. Arachidonic acid enhances intracellular [Ca2+]i increase and mitochondrial depolarization induced by glutamate in cerebellar granule cells. Biochemistry (Mosc). 2006. V. 71. N. 8. P. 864-870.
  62. Vinogradova L.V., Vinogradov V.Y., Kuznetsova G.D. Unilateral cortical spreading depression is an early marker of audiogenic kindling in awake rats. Epilepsy Research. 2006. V. 71. N. 1. P. 64-75. DOI: 10.1016/j.eplepsyres.2006.05.014.
  63. Vinogradova L.V., Kuznetsova G.D., Coenen A.M. Audiogenic seizures associated with a cortical spreading depression wave suppress spike-wave discharges in rats. Physiology and Behavior. 2005. V. 86. N. 4. P. 554-558. DOI: 10.1016/j.physbeh.2005.08.017.
  64. Vinogradova L.V., Kuznetsova G.D., Shatskova A.B., VanRijn C.M. Vigabatrin in low doses selectively suppresses the clonic component of audiogenically kindled seizures in rats. Epilepsia. 2005. V. 46. N. 6. P. 800-810. DOI: 10.1111/j.1528-1167.2005.52604.x.
  65. Vinogradova L.V. Audiogenic kindling in WAG/Rij rats: change in behavioral and electrophysiological responses to repetitive short acoustic stimulation. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2004. V. 54. N. 5. P. 638-647.
  66. Midzyanovskaya I.S., Kuznetsova G.D., Vinogradova L.V., Shatskova A.B., Coenen A.M., VanLuijtelaar G. Mixed forms of epilepsy in a subpopulation of WAG/Rij rats. Epilepsy and Behavior. 2004. V. 5. N. 5. P. 655-661. DOI: 10.1016/j.yebeh.2004.06.021.
  67. Bolshakov A.P., Onufriev M.V., Khanicheva N.A., Stepanichev M.Y., Chabak-Garbach R.., Ajrapetiantz M.G., Gulyaeva N.V. Effect of early social isolation on nitric oxide synthase activity in rat brain. Nejrokhimija. 2001. V. 18. P. 262-266.
  68. Koroleva V.I., Vinogradova L.V. Ischemic and hypoxic depolarization in the rat neocortex. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2000. V. 50. N. 4. P. 612-623.
  69. Koroleva V.I., Vinogradova L.V., Korolev O.S. The persistent negative potential provoked in different structures of the rat brain by a single wave of spreading cortical depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1998. V. 48. N. 4. P. 654-663.
  70. Vinogradova L.V., Koroleva V.I. Spreading depression in the corticostriatal system of the rat brain during a seizure process induced by the daily administration of pentylenetetrazole. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1993. V. 43. N. 4. P. 683-694.
  71. Koroleva V.I., Vinogradova L.V., Bures J. Reduced incidence of cortical spreading depression in the course of pentylenetetrazol kindling in rats. Brain Research. 1993. V. 608. N. 1. P. 107-114. DOI: 10.1016/0006-8993(93)90780-Q.
  72. Sharova E.V., Borodkin O.M., Gogitidze N.V., Lukyanov E.V., Mukhanov T.K. Functional significance of parameters of EEG spatial-temporal organization in patients with cranial-cerebral trauma. Fiziologiya Cheloveka. 1992. V. 18. N. 6. P. 22-30.
  73. Sharova E.V., Borodkin S.M., Gogitidze N.V., Lukyanov E.V., Mukhanov T.K. Functional significance of the characteristics of the spatio-temporal organization of EEG in patients with traumatic brain injury. Fiziologija Cheloveka. 1992. V. 18. N. 6. P. 22-30.
  74. Koroleva V.I., Gorelova N.A., Vinogradova L.V. The electrophysiological characteristics and behavioral manifestations of hippocampal and thalamic spreading depression. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 1991. V. 41. N. 5. P. 1019-1032.
  75. Vinogradova L.V., Koroleva V.I., Bures J. Re-entry waves of Leao's spreading depression between neocortex and caudate nucleus. Brain Research. 1991. V. 538. N. 1. P. 161-164. DOI: 10.1016/0006-8993(91)90392-9.
  76. Koroleva V.I., Vinogradova L.V. Spreading depression in the thalamus, hippocampus and caudate nucleus of the rat during electrical stimulation of the parietal area of the cortex. Nejrofiziologija. 1990. V. 22. N. 1. P. 36-44.
 

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