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Yulia S. Mednikova

D.Sc. in Biology, Leading Scientist

spontaneous activity, dendrites, acetylcholine, ionic homeostasis

Laboratory of Functional Neurocytology

Scopus ID
6602755986
ORCID ID
0000-0002-1442-4547
Web of Science ResearcherID
E-1809-2014
SPIN code
8071-5332

Had graduated from the Faculty of Biology of Lomonosov Moscow State University in 1970 with a degree in biology and physiology of humans and animals.

PhD in Biology 1977

Doctor of Biological Sciences 2006

Had published more than 50 articles in domestic and foreign journals.

Main scientific results. It was determined that:

1) spontaneous activity of neurons is involved in the formation of adaptive reactions of the brain,

2) non-specific growth of impulsation is formed due to the passage of glutamatergic excitation through the dendrites and is regulated by acetylcholine,

3) M-cholinergic reaction is a metabolic temperature and energy dependent process,

4) a powerful increase in the rate of the M-cholinergic reaction at t = 35-36 degrees Celsius determines

the high dependence of the brain of warm-blooded animals on the lack of energy supply.

Publication list

  1. Mednikova Yu.S., Voronkov D.N., Khudoerkov R.M., Pasikova N.V., Zakharova N.M. The active and passive components of neuronal excitation and its glial support. Biophysics. 2021. V. 66. N. 11. P. 756-773. DOI: 10.31857/S0006302921040165.
  2. Mednikova Y.S., Voronkov D.N., Khudoerkov R.M., Pasikova N.V., Zakharova N.M. The Active and Passive Components of Neuronal Excitation and its Glial Support. Biophysics (Russian Federation). 2021. V. 66. N. 4. P. 642-656. DOI: 10.1134/S0006350921040126.
  3. Mednikova Y.S., Zakharova N.M., Pasikova N.V. Functional and pathological influence of hypothermia on spike activity of cortical neurons. Journal of Behavioral and Brain Science. 2021. V. 11. P. 107-130. DOI: 10.4236/jbbs.2021.115009.
  4. Mednikova Y.S., Kalabushev S.N. EVOLUTIONARY AND BEHAVIORAL EXPANSION OF THE RANGE OF SPONTANEOUS ACTIVITY OF COLD-BLOOD NEURONS. Journal of Evolutionary Biochemistry and Physiology. 2020. V. 56. N. 7. P. 641. DOI: 10.31857/s0044452920070931.
  5. Mednikova Y.S., Rogal A.V. Heterogeneity of the neural composition of cortical regions as a condition for a wide range regulating spontaneous activity. Journal of Behavioral and Brain Science. 2020. V. 10. P. 220-236. DOI: 10.4236/jbbs.2020.105014.
  6. Mednikova Y.S., Kozlov M., Makarenko A. Energy Aspects of Sodium Thiopental Action on Nervous Activity. Journal of Behavioral and Brain Science. 2019. V. 9. N. 9. P. 33-53. DOI: 10.4236/jbbs.2019.92004.
  7. Zaharova N.M., Voronkov D.N., Hudoerkov R.M., Pasikova N.V., Mednikova Y.S. GLIO-NEURONAL RELATIONS IN THE SENSOMOTOR CORK OF WARM-BLOOD ANIMALS WITH DIFFERENT HABITATING CONDITIONS (GUINEA PIGS AND WHIPES) AND M-CHOLINERGIC BRAIN RESPONSE. Biophysics. 2018. V. 63. N. 2. P. 294-302.
  8. Zakharova N.M., Voronkov D.N., Khudoerkov R.M., Pasikova N.V., Mednikova Y.S. Glia–Neuron Interactions in the Sensory-Motor Cortex of Warm-Blooded Animals (Guinea Pigs and Ground Squirrels) with Different Habitat Conditions and the M-Cholinergic Reaction of the Brain. Biophysics (Russian Federation). 2018. V. 63. N. 2. P. 207-214. DOI: 10.1134/S0006350918020264.
  9. Mednikova Y.S., Zaharova N.M., Pasikova N.V., Voronkov D.N. COMPARATIVE ANALYSIS OF MORPHOFUNCTIONAL PECULIARITIES OF CORTAL NEURONS OF GERMAN AND PINE PIGS AT CHANGE IN THEIR ACTIVITY UNDER HYPOTHERMIA. JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY. 2017. V. 53. N. 4. P. 295-302.
  10. Mednikova Y.S., Pasikova N.V., Zakharova N.M., Averina I.V. Glutamatergic Excitation of Cortical Neurons Depending on the Point of Origin on the Membrane and Cholinergic Regulation in Hypothermia. Neuroscience and Behavioral Physiology. 2016. V. 46. N. 3. P. 328-337. DOI: 10.1007/s11055-016-0237-6.
  11. Mednikova Y.S., Pasikova N.V., Zaharova N.M., Averina A.V. Glutamatergic excitation of cortical neurons depending on the point of its origin on the membrane and cholinergic regulation under conditions of hypothermia. Russian physiological journal. I.M.Sechenov. 2014. V. 100. N. 9. P. 1008-1024.
  12. Kozhechkin S.N., Mednikova Y.S., Kolik L.G. Electrophysiological study of the effects of topiramate on neocortical neurons in rats. Eksperimental'naya i Klinicheskaya Farmakologiya. 2014. V. 77. N. 8. P. 3-6.
  13. Mednikova Yu.S., Khokhlova V.N., Koshtoyants O.Kh. Glutamatergic basis of impulse responses of cortical neurons to sensory stimulation. Sensory Systems. 2013. V. 27. N. 3. P. 257-268.
  14. Kozhechkin S., Mednikova Y.S., Kolik L.G. Effects of naltrexone on firing activity of rat cortex neurons and its interactions with ethanol. Bulletin of Experimental Biology and Medicine. 2013. V. 155. N. 5. P. 639-642. DOI: 10.1007/s10517-013-2214-1.
  15. Kozhechkin S.N., Mednikova Y.S., Kolik L.G. Electrophysiological study of acamprosate effects on frontal cortical neurons in rats. Eksperimental'naya i Klinicheskaya Farmakologiya. 2013. V. 77. N. 6. P. 3-6.
  16. Pasikova N.V., Mednikova Y.S., Voronkov D.N., Khudoerkov R.M., Kopytova F.V. Glial satellite cells as a source of supplementary energy supply for neurons during spike activity at elevated frequency. Neuroscience and Behavioral Physiology. 2013. V. 43. N. 2. P. 144-149. DOI: 10.1007/s11055-013-9705-4.
  17. Mednikova Yu.S., Kozhechkin S.N., Kopytova F.V., Koshtoyants O.Kh. Adaptive function of the brain and hypoxia problems. Pathologic phisiology and experimental therapy. 2012. N. 3. P. 33-41.
  18. Pasikova N.V., Mednikova Y.S., Voronkov D.N., Khudoerov R.M., Kopytova F.V. Glial satellites as the source of additional energy supply to the neurons during the increased frequency of firing activity. Morfologija. 2012. V. 141. N. 1. P. 33-38.
  19. Pasikova N.V., Mednikova Y.S., Averina I.V. Thermal regulation of spontaneous spike frequency and concomitant changes in the amplitude of spikes from cortical neurons. Neuroscience and Behavioral Physiology. 2011. V. 41. N. 7. P. 696-702. DOI: 10.1007/s11055-011-9474-x.
  20. Pasikova N.V., Mednikova Y.S., Averina I.V. The temperature regulation of the spontaneous activity frequency and the concomitant changes of the cortical neurons' spike amplitude. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2010. V. 96. N. 3. P. 315-324.
  21. Mednikova Y.S., Kopytova F.V., Zhadin M.N. Spontaneous activity of cortical neurons in vitro and its regulation by acetylcholine. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 9. P. 986-992. DOI: 10.1007/s11055-010-9357-6.
  22. Mednikova Y.S., Kopytova F.V., Zhadin M.N. Levels of spontaneous activity and spike responses of cortical neurons to local administration of excitatory amino acids to their dendrites and bodies. Neuroscience And Behavioral Physiology. 2009. V. 39. N. 5. P. 429-35. DOI: 10.1007/s11055-009-9159-x.
  23. Mednikova Y.S., Kopytova F.V., Zhadin M.N. Spontaneous impulsation and features of reactions to local excitation of dendrites. Neurological bulletin. 2008. V. 40. N. 1. P. 5-9.
  24. Mednikova Y.S., Pasikova N.V., Isakova A.V., Kopytova F.V. Cholinergic process and functional state of cortical neurons under conditions of artificial incubation. Neurochemical Journal. 2008. V. 2. N. 1-2. P. 115-119.
  25. Isakova A., Mednikova Y.S. Comparative roles of acetylcholine and noradrenaline in controlling the spontaneous activity of cortical neurons. Neuroscience and Behavioral Physiology. 2007. V. 37. N. 7. P. 689-696. DOI: 10.1007/s11055-007-0069-5.
  26. Kopytova F., Mednikova Y.S. Characterization of formation and trace rhythm reproduction by rabbit hippocampal neurons during early and late ontogeny. Bulletin of Experimental Biology and Medicine. 2007. V. 143. N. 3. P. 287-290. DOI: 10.1007/s10517-007-0091-1.
  27. Isakova A.V., Mednikova Y.S. The comparative roles of acetylcholine and noradrenaline in regulation of spontaneous spike activity of cortical neurons. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2006. V. 56. N. 5. P. 664-673.
  28. Mednikova Y.S., Pasikova N.V. The temperature sensitivity of the cholinergic responses of cortical neurons in the guinea pig brain. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 6. P. 615-621. DOI: 10.1007/s11055-005-0101-6.
  29. Mednikova Y.S., Pasikova N.V. Temperature sensitivity of the cholinergic response in cortical neurons of guinea pigs. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2004. V. 90. N. 2. P. 193-201.
  30. Kopytova F., Mednikova Y.S., Popova E.N. Age-related structural and functional characteristics of rabbit hippocampal neurons during the formation of temporal associations. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 9. P. 889-896. DOI: 10.1023/B:NEAB.0000042573.05342.95.
  31. Mednikova Y.S., Pasikova N.V., Kopytova F.V. Effects of temperature on the spike activity of cortical neurons in guinea pigs. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 5. P. 459-465. DOI: 10.1023/B:NEAB.0000022630.53594.99.
  32. Mednikova Y.S., Karnup S.V., Zhadin M.N. Cholinergic modulation of neuron spike responses to dendritic and somatic application of excitatory amino acids. Neuroscience and Behavioral Physiology. 2003. V. 33. N. 6. P. 579-588. DOI: 10.1023/A:1023930703926.
  33. Mednikova Y.S., Pasikova N.V., Kopytova F.V. Effect of temperature on impulse activity of cortical neurons in guinea pigs. Rossijskij Fiziologicheskij Zhurnal im I M Sechenova. 2002. V. 88. N. 11. P. 1492-1500.
  34. Mednikova Y.S., Karnup S.V., Zhadin M.N. Cholinergic Modulation of Neuronal Spike Reactions to Dendritic and Somatic Application of Excitatory Amino Acids. Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 2002. V. 52. N. 4. P. 487-488.
  35. Mednikova Y.S., Kopytova F.V., Dish T.N. Spike responses of neurons in the motor area of the cortex of elderly rabbits to specific stimuli. Neuroscience and Behavioral Physiology. 2001. V. 31. N. 3. P. 245-253. DOI: 10.1023/A:1010322231842.
  36. Mednikova Y.S., KOPYTOVA F.V., DISH T.N. SPIKE REACTIONS OF MOTOR CORTEX NEURONS OF ELDERLY RABBITS TO SPECIFIC AFFERENT STIMULATION. ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I.P. PAVLOVA. 2000. V. 50. N. 2. P. 303-315.
  37. Mednikova Y.S., Karnup S.V., Loseva E.V. Cholinergic excitation of dendrites in neocortical neurons. Neuroscience. 1998. V. 87. N. 4. P. 783-796. DOI: 10.1016/s0306-4522(98)00166-3.
  38. Kopytova F.V., Mednikova Y.S. Rhythmic stimulation: influence on periodic processes and functional state of cortical neurons during aging. Russian Journal of Physiology. 1996. V. 82. N. 10-11. P. 122-125.
  39. Mednikova Y.S., Loseva E.V., Karnup S.V., Zhadin M.N. Reactions of cortical neurons to microiontophoretic supply of acetylcholine to their dendrites. I.P. Pavlov Journal of Higher Nervous Activity. 1996. V. 46. N. 5. P. 893-903.
  40. Mednikova Y.S., Kopytova F.V., Dish T.N. Features of responses of neurons in the motor cortex of old rabbits to specific stimulation. Russian Journal of Physiology. 1995. V. 81. N. 8. P. 173-175.
  41. Mednikova Y.S., Karnup S.V. Functional geometry of amino acid sensitive membrane of layer V neurons in the guinea-pig neocortex in vitro. Neuroscience. 1995. V. 69. N. 1. P. 115-123. DOI: 10.1016/0306-4522(95)00189-p.
  42. Mednikova Y.S., Kopytova F.V. Some physiological characteristics of motor cortex neurons of aged rabbits. Neuroscience. 1994. V. 63. N. 2. P. 611-615. DOI: 10.1016/0306-4522(94)90554-1.
  43. Mednikova Yu.S., Karnup S.V. Responses of cortical neurons to local supply of excitatory amino acids to dendrites and soma. Neurophysiology. 1993. V. 1. N. 6. P. 437-445.
  44. Mednikova Yu.S., Kopytova F.V. Cholinosensitivity as an indicator of functional differences between neurons in young and old rabbits. I.P. Pavlov Journal of Higher Nervous Activity. 1991. V. 41. N. 6. P. 1222-1230.
  45. Mednikova Yu.S. Influence of microiontophoretic supply of acetylcholine on the formation of conditioned reactions in neurons of the motor cortex. I.P. Pavlov Journal of Higher Nervous Activity. 1989. V. 34. N. 4. P. 691-698.
  46. Mednikova Yu.S. Effect of microiontophoretic supply of acetylcholine and noradrenaline on the reactivity of motor cortex neurons to specific stimuli. Scientific reports of higher school. Biological Sciences. 1988. N. 2. P. 40-47.
  47. Mednikova Yu.S. Activity of neurons in the motor cortex during the development of a local instrumental defensive reflex in rabbits. I.P. Pavlov Journal of Higher Nervous Activity. 1983. V. 33. N. 6. P. 1067-1072.
 

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