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Mikhail Yu. Stepanichev

D.Sc. in Biology, Leading Scientist

brain, aging, Alzheimer's disease, neurodegeneration, learning, memory, neurotrophic factors, neuroplasticity, stress, epilepsy, depression, oxidative stress, free radicals, nitric oxide

Laboratory of Functional Biochemistry of the Nervous System

Scopus ID
6701546567
ORCID ID
0000-0001-8109-8692
Web of Science ResearcherID
J-8022-2018
SPIN code
1669-4477

Undergraduate                       Chemistry and Biology

Leo Tolstoy’s State Pedagogical Institute, Tula (1985-1990)

                                   Title: “Spectral behavior of sigma-complexes in different solvents”

                                   Supervisors: Dr. T. Golopolosova (Chemistry)

                                                        Dr. E. Alifanova (Chemistry)

 

PhD                            Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (1992-1997)

                                   Title: “Neurochemical correlates of individual behavior in rats”

                                   Supervisor: Prof. N. Gulyaeva (Physiology)

 

DSci                           Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (2010)

Title: “Behavioral impairments and structural-functional changes in rat brain during modeling of neurodegeneration”

 

 

Post-D                         Dept. Functional Biochemistry of the Nervous System,

                                   Institute of Higher Nervous Activity & Neurophysiology 

                                   Russian Academy of Sciences (2011-pres.)

 

Publication list

  1. Peregud D., Stepanichev M.Yu., Gulyaeva N.V. Expression of the hippocampal PTCH during early abstinence is associated with drinking patterns in a rat model of voluntary alcohol intake. Neuroreport. 2021. V. 32. N. 9. P. 757-761. DOI: 10.1097/WNR.0000000000001646.
  2. Stepanichev M.Y., Goryakina T., Manolova A., Lazareva N., Kvichanskii A., Tretyakova L., Volobueva M., Gulyaeva N. Neonatal proinflammatory challenge evokes a microglial response and affects the ratio between subtypes of GABAergic interneurons in the hippocampus of juvenile rats: sex-dependent and sex-independent effects. Brain Structure and Function. 2021. V. 226. N. 2. P. 563-574. DOI: 10.1007/s00429-020-02199-z.
  3. Bolshakov A.P., Stepanichev M.Y., Dobryakova Y.V., Spivak Y.S., Markevich V.A. Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience. Toxins. 2020. V. 12. N. 9. P. 546. DOI: 10.3390/toxins12090546.
  4. Kudryashova I., Stepanichev M., Manolova A., Gulyaeva N. Deficit of Long-Term Potentiation Induction, but Not Maintenance, in the Juvenile Hippocampus after Neonatal Proinflammatory Stress. Developmental Neuroscience. 2020. V. 41. N. 5-6. P. 318-326. DOI: 10.1159/000507347.
  5. Peregud D.I., Stepanichev M.Yu., Gulyaeva N.V. Drinking Pattern in Intermittent Access Two-Bottle-Choice Paradigm in Male Wistar Rats Is Associated with Exon-Specific BDNF Expression in the Hippocampus During Early Abstinence. Journal Of Molecular Neuroscience. 2020. V. 71. N. 2. P. 262-275. DOI: 10.1007/s12031-020-01645-1.
  6. Stepanichev M.Yu. Gene Editing and Alzheimer's Disease: Is There Light at the End of the Tunnel?. Frontiers in Genome Editing. 2020. V. 2. P. 4. DOI: 10.3389/fgeed.2020.00004.
  7. Dobryakova Y.V., Kasianov A., Zaichenko M.I., Stepanichev M.Y., Chesnokova E.A., Kolosov P.M., Markevich V.A., Bolshakov A.P. Intracerebroventricular administration of <sup>192</sup>IgG-saporin alters expression of microglia-associated genes in the dorsal but not ventral hippocampus. Frontiers in Molecular Neuroscience. 2018. V. 10. P. 429. DOI: 10.3389/fnmol.2017.00429.
  8. Stepanichev M.Yu., Manolova A.O., Peregud D.I., Onufriev M.V., Freiman S., Aniol V.A., Moiseeva Y.V., Novikova M.R., Lazareva N.A., Gulyaeva N.V. Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats. Neuroscience. 2018. V. 375. P. 49-61. DOI: 10.1016/j.neuroscience.2018.02.007.
  9. Stepanichev M.Yu., Onufriev M., Aniol V.A., Freiman S., Brandstaetter H., Winter S., Lazareva N., Guekht A., Gulyaeva N.V. Effects of cerebrolysin on nerve growth factor system in the aging rat brain. Restorative Neurology and Neuroscience. 2017. V. 35. N. 6. P. 571-581. DOI: 10.3233/RNN-170724.
  10. Peregud D.I., Stepanichev M.Y., Lazareva N.A., Panchenko L.F., Gulyaeva N.V. Influence of single injection of neurotrophic factor into mid tire area on supporting properties of morphine. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. 632–640.
  11. Peregud D.I., Freiman S.V., Tishkina A.O., Sokhranyaeva L.S., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats. Vavilovskij Zhurnal Genetiki i Selektsii. 2016. V. 20. N. 2. P. 191-197.
  12. Stepanichev M.Y., Ivanov A.D., Lazareva N.A., Moiseeva Y.V., Gulyaeva N.V. Neurodegenerative changes caused by the introduction of a fragment (25–35) of a β-amyloid peptide into the hippocampus are associated with activation of NGF signaling. Vestnik RGMU. 2016. V. 1. N. 1. P. 14-19.
  13. Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omeljanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Mojseenok A.G., Gulyaeva N.V. Pantothenic acid derivatives when used with memantine reduce scopolamine-induced amnesia in rats: participation of the redox state of thiols and coenzyme A. Nejrokhimija. 2016. V. 33. N. 2. P. 128-139.
  14. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshyna I.P., Piskunov A.K., Lazareva N.A., Gulyaeva N.V. Effects of Chronic Combined Stress: Changes in the Behavior of Rats with a Different Reaction to Novelty. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2016. V. 66. N. 5. P. 611-625.
  15. Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Stressogenic effects of a single injection of saline: systemic (blood) and central (frontal cortex, dorsal and ventral hippocampus). Najrokhimija. 2016. V. 33. N. 2. P. 122-127.
  16. Freiman S.V., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. The stress effects of a single injection of isotonic saline solution: systemic (blood) and central (frontal cortex and dorsal and ventral hippocampus). Neurochemical Journal. 2016. V. 10. N. 2. P. 115-119. DOI: 10.1134/S1819712416020033.
  17. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cellular and Molecular Neurobiology. 2016. V. 36. N. 6. P. 839-849. DOI: 10.1007/s10571-015-0267-6.
  18. Piskunov A., Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I., Gulyaeva N.V. Chronic combined stress induces selective and long-lasting inflammatory response evoked by changes in corticosterone accumulation and signaling in rat hippocampus. Metabolic Brain Disease. 2016. V. 31. N. 2. P. 445-454. DOI: 10.1007/s11011-015-9785-7.
  19. Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033.
  20. Stepanichev M.Y., Markov D., Pasikova N.V., Gulyaeva N.V. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural Brain Research. 2016. V. 297. P. 5-14. DOI: 10.1016/j.bbr.2015.09.033.
  21. Stepanichev M.Y., Markov D.A., Freiman S.V., Frolova O.A., Omelyanchik S.N., Borodina T.A., Novikova M.R., Kanunnikova N.P., Onufriev M.V., Moiseenok A.G., Gulyaeva N.V. Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A. Neurochemical Journal. 2016. V. 10. N. 2. P. 120-130. DOI: 10.1134/S1819712416020094.
  22. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031.
  23. Stepanichev M.Y., Tishkina A.O., Novikova M.R., Levshina I.P., Freiman S.V., Onufriev M.V., Levchenko O.A., Lazareva N.A., Gulyaeva N.V. Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. Acta Neurobiologiae Experimentalis. 2016. V. 76. N. 4. P. 324-333. DOI: 10.21307/ane-2017-031.
  24. Tishkina A.O., Stepanichev M.Y., Kudryashova I.V., Freiman S., Onufriev M.V., Lazareva N.A., Gulyaeva N.V. Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response. Behavioural Brain Research. 2016. V. 304. P. 1-10. DOI: 10.1016/j.bbr.2016.02.001.
  25. Komoltsev I.G., Levshyna I.P., Novikova M.R., Stepanichev M.Y., Tishkina A.O., Gulyaeva N.V. Changes in brain cortex after dozing head inhury in rats with different age. Morphologija. 2015. V. 148. N. 5. P. 14-20.
  26. Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Martianov E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. Expression of TrkA and TrkB neurotrophins high affinity receptors in rat hippocampus after intracerebroventricular administration of βA (25-35). Nejrokhimija. 2015. V. 32. N. 1. P. 57-63.
  27. Dygalo N.N., Stepanichev M.Y., Gulyaeva N.V., Shishkina G.T. Expression of genes in the brain associated with depression. Russian Journal of Genetics: Applied Research. 2015. V. 5. N. 6. P. 582-588. DOI: 10.1134/S2079059715060027.
  28. Stepanichev M.Y., Tishkina A.O., Lazareva N.A., Mart'yanova E.K., Tukhbatova G.R., Kulagina A.O., Salozhin S.V., Gulyaeva N.V. The expression of the TrkA and TrkB high-affinity neurotrophin receptors in the rat hippocampus after intracerebroventricular administration of Aβ(25–35). Neurochemical Journal. 2015. V. 9. N. 1. P. 47-53. DOI: 10.1134/S1819712415010110.
  29. Stepanichev M., Lazareva N., Tukhbatova G., Salozhin S., Gulyaeva N. Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction. Behavioural Brain Research. 2014. V. 259. P. 152-157. DOI: 10.1016/j.bbr.2013.11.013.
  30. Stepanichev M.Y., Lazareva N.A., Tukhbatova G.R., Salozhin S., Gulyaeva N.V. Transient disturbances in contextual fear memory induced by Aβ(25-35) in rats are accompanied by cholinergic dysfunction. Behavioural Brain Research. 2014. V. 259. P. 152-157. DOI: 10.1016/j.bbr.2013.11.013.
  31. Gulyaeva N.V., Stepanichev M.Y. The anti-AD cookbook: A new recipe. Journal of Neurochemistry. 2013. V. 125. N. 1. P. 4-6. DOI: 10.1111/jnc.12138.
  32. Stepanichev M.Yu., Onufriev M.V., Piskunov A.K., Moiseeva Y.V., Lazareva N.A., Moiseenok A.G., Gusev P.V., Gulyaeva N.V. The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress. Neurochemical Journal. 2013. V. 7. N. 2. P. 144-149. DOI: 10.1134/S1819712413020062.
  33. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Bull Exp Biol Med.. 2012. V. 153. N. 6. P. 835-838.
  34. Tishkina A.O., Rukhlenko A., Stepanichev M.Yu., Levshina I., Pasikova N.V., Onufriev M.V., Moiseeva Y.V., Piskunov A., Gulyaeva N.V. Region-specific changes in activities of cell death-related proteases and nitric oxide metabolism in rat brain in a chronic unpredictable stress model. Metabolic Brain Disease. 2012. V. 27. N. 4. P. 431-41. DOI: 10.1007/s11011-012-9328-4.
  35. Aniol V.A., Stepanichev M.Y., Lazareva N.A., Gulyaeva N.V. An early decrease in cell proliferation after pentylenetetrazole-induced seizures. Epilepsy and Behavior. 2011. V. 22. N. 3. P. 433-441. DOI: 10.1016/j.yebeh.2011.08.002.
  36. Tukhbatova G.R., Kuleshova E.P., Stepanichev M.Y., Ivanov A.D., Salozhin S.V. Optimization of a preparation of lentiviral particles for transduction of neurons in vivo. Neurochemical Journal. 2011. V. 5. N. 4. P. 294-300. DOI: 10.1134/S1819712411040179.
  37. Antipova T.A., Sapozhnikova D.S., Stepanichev M.Y., Onufriev M.V., Gulyaeva N.V., Seredenin S.B. Effects of selective anxiolytic afobazole on active caspase-3. Bulletin of Experimental Biology and Medicine. 2010. V. 149. N. 2. P. 201-203. DOI: 10.1007/s10517-010-0907-2.
  38. Gulyaeva N.V., Stepanichev M.Y. AΒ(25-35) as proxyholder for amyloidogenic peptides: In vivo evidence. Experimental Neurology. 2010. V. 222. N. 1. P. 6-9. DOI: 10.1016/j.expneurol.2009.12.019.
  39. Pavlova T.V., Stepanichev M.Y., Gekht A.B., Gulyaeva N.V. Acquisition of an active avoidance reaction in rats and morphological changes in the hippocampus in pentylenetetrazol kindling. Neuroscience and Behavioral Physiology. 2010. V. 40. N. 5. P. 501-506. DOI: 10.1007/s11055-010-9288-2.
  40. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Changes in cell proliferation in the subventricular zone of the brain in adult rats given β-amyloid peptide (25-35). Neuroscience and Behavioral Physiology. 2010. V. 40. N. 2. P. 123-126. DOI: 10.1007/s11055-009-9232-5.
  41. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Changes in cell proliferation in the subventricular zone of the brain in adult rats given β-amyloid peptide (25-35). Neuroscience and Behavioral Physiology. 2010. V. 40. N. 2. P. 123-126. DOI: 10.1007/s11055-009-9232-5.
  42. Kudryashova I.V., Stepanichev M.Y., Gulyaeva N.V. Natural activation of caspase-3 is required for the development of operant behavior in postnatal ontogenesis. Neuroscience and Behavioral Physiology. 2009. V. 39. N. 1. P. 65-72. DOI: 10.1007/s11055-008-9097-z.
  43. Onufriev M.V., Yakovlev A.A., Lyzhin A.A., Stepanichev M.Y., Khaspekov L.G., Gulyaeva N.V. A secreted caspase-3-substrate-cleaving activity at low pH belongs to cathepsin B: A study on primary brain cell cultures. Biochemistry (Moscow). 2009. V. 74. N. 3. P. 281-287. DOI: 10.1134/S0006297909030067.
  44. Tishkina A.O., Levshina I.P., Lazareva N.A., Pasikova N.V., Stepanichev M.Y., Ajrapetyanz M.G., Gulyaeva N.V. Chronic stress induces nonapoptotic neuronal death in the rat hippocampus. Doklady Biological Sciences. 2009. V. 428. N. 1. P. 403-406. DOI: 10.1134/S0012496609050032.
  45. Stepanichev M.Y., Onufriev M.V., Yakovlev A.A., Khrenov A.I., Peregud D.I., Vorontsova O.N., Lazareva N.A., Gulyaeva N.V. Amyloid-β (25-35) increases activity of neuronal NO-synthase in rat brain. Neurochemistry International. 2008. V. 52. N. 6. P. 1114-1124. DOI: 10.1016/j.neuint.2007.11.009.
  46. Bravarenko N.I., Onufriev M.V., Stepanichev M.Y., Ierusalimsky V.N., Balaban P.M., Gulyaeva N.V. Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix. European Journal of Neuroscience. 2006. V. 23. N. 1. P. 129-140. DOI: 10.1111/j.1460-9568.2005.04549.x.
  47. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity?. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 7. P. 741-748. DOI: 10.1007/s11055-006-0082-0.
  48. Stepanichev M.Y., Zdobnova I., Zarubenko I., Lazareva N.A., Gulyaeva N.V. Differential effects of tumor necrosis factor-alpha co-administered with amyloid beta-peptide (25-35) on memory function and hippocampal damage in rat. Behavioural Brain Research. 2006. V. 175. N. 2. P. 352-361. DOI: 10.1016/j.bbr.2006.09.006.
  49. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Gulyaeva N.V. Studies of the effects of central administration of β-amyloid peptide (25-35): Pathomorphological changes in the hippocampus and impairment of spatial memory. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 101-106. DOI: 10.1007/s11055-005-0167-1.
  50. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Lazareva N.A., Gulyaeva N.V. Studies of the effects of central administration of β-amyloid peptide (25-35): Pathomorphological changes in the hippocampus and impairment of spatial memory. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 1. P. 101-106. DOI: 10.1007/s11055-005-0167-1.
  51. Stepanichev M.Y., Kudryashova I.V., Yakovlev A.A., Onufriev M.V., Khaspekov L.G., Lyzhin A.A., Lazareva N.A., Gulyaeva N.V. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience. 2005. V. 136. N. 2. P. 579-591. DOI: 10.1016/j.neuroscience.2005.08.010.
  52. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Gulyaeva N.V. Studies of the effects of fragment (25-35) of beta-amyloid peptide on the behavior of rats in a radial maze. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 5. P. 511-518. DOI: 10.1007/s11055-005-0086-1.
  53. Zarubenko I.I., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Electroconvulsive shock induces neuron death in the mouse hippocampus: Correlation of neurodegeneration with convulsive activity. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 7. P. 715-721. DOI: 10.1007/s11055-005-0115-0.
  54. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritskii A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 1. P. 45-47. DOI: 10.1023/B:NEAB.0000003246.26997.10.
  55. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003.
  56. Stepanichev M.Y., Zdobnova I.M., Zarubenko I.I., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Amyloid-β(25-35)-induced memory impairments correlate with cell loss in rat hippocampus. Physiology and Behavior. 2004. V. 80. N. 5. P. 647-655. DOI: 10.1016/j.physbeh.2003.11.003.
  57. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 110-113.
  58. Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3′,5′-monophosphate levels in structures of the "Informational" and "Motivational" systems of the rat brain during acquistion of a conditioned active avoidance reaction. Neuroscience and Behavioral Physiology. 2003. V. 33. N. 4. P. 329-333. DOI: 10.1023/A:1022887321863.
  59. Gulyaeva N.V., Thompson C., Shinohara N., Lazareva N.A., Onufriev M.V., Stepanichev M.Y., Moiseeva Y.V., Fliss H., Hakim A.M. Tongue protrusion: A simple test for neurological recovery in rats following focal cerebral ischemia. Journal of Neuroscience Methods. 2003. V. 125. N. 1-2. P. 183-193. DOI: 10.1016/S0165-0270(03)00056-6.
  60. Stepanichev M.Y., Moiseeva Y.V., Lazareva N.A., Onufriev M.V., Gulyaeva N.V. Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats. Brain Research Bulletin. 2003. V. 61. N. 2. P. 197-205. DOI: 10.1016/S0361-9230(03)00118-7.
  61. Stepanichev M.Y., Zdobnova I.M., Yakovlev A.A., Onufriev M.V., Lazareva N.A., Zarubenko I.I., Gulyaeva N.V. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). Journal of Neuroscience Research. 2003. V. 71. N. 1. P. 110-120. DOI: 10.1002/jnr.10469.
  62. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) induces changes in long-term potentiation in the hippocampus in vivo. Neuroscience and behavioral physiology. 2003. V. 33. N. 2. P. 95-98. DOI: 10.1023/A:1021761310435.
  63. Egorova L.K., Stepanichev M.Y., Mikhalev S.L., Kutepova O.A., Gulyaeva N.V. Analysis of cyclic adenosine-3',5'-monophosphate levels in structures of the "informational" and "motivational" systems of the rat brain during acquisition of a conditioned active avoidance reaction. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2002. V. 52. P. 235-240.
  64. Zdobnova I.M., Stepanichev M.Y., Yakovlev A.A., Onufriev M.V., Egorova L.K., Moiseeva Y.V., Lazareva N.A., Matz V.N., Gulyaeva N.V. The interaction of the neurotoxic fragment of the beta-amyloid peptide and tumor necrosis factor alpha with intracerebral administration to rats. Nejrokhimija. 2002. V. 19. P. 117-122.
  65. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole Kindling causes oxidative stress in rat brain. Nejrokhimija. 2002. V. 19. P. 123-126.
  66. Stepanichev M.Y., Moiseeva Y.V., Gulyaeva N.V. "Injection" models of Alzheimer's disease: oxidative stress in the toxicity mechanism of AF64A and β-amyloid peptide in rodents. Nejrokhimija. 2002. V. 19. P. 165-175.
  67. Bolshakov A.P., Onufriev M.V., Khanicheva N.A., Stepanichev M.Y., Chabak-Garbach R.., Ajrapetiantz M.G., Gulyaeva N.V. Effect of early social isolation on nitric oxide synthase activity in rat brain. Nejrokhimija. 2001. V. 18. P. 262-266.
  68. Moiseeva Y.V., Onufriev M.V., Lazareva N.A., Stepanichev M.Y., Gulyaeva N.V. Free-radical mechanisms of septo-hippocampal neurodegeneration caused by cholinotoxin AF64A in rats in vivo. Nejrokhimija. 2001. V. 18. P. 287-289.
  69. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Administration of aggregated beta-amyloid peptide (25-35) causes change in long-term potentiation in the hippocampus. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2001. V. 51. N. 6. P. 690-693.
  70. Trubetskaya V.V., Stepanichev M.Y., Onufriev M.V., Lazareva N.A., Markevich V.A., Gulyaeva N.V. Increase in activity of NO-synthetase in rat's hippocampus follows long-term potentiation in vivo. Nejrokhimiya. 2001. V. 18. N. 1. P. 55-61.
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