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Alexander A. Yakovlev

D.Sc. in Biology, Senior Scientist

Laboratory of Functional Biochemistry of the Nervous System

Scopus ID
7202348049
ORCID ID
0000-0003-2546-5130
Web of Science ResearcherID
E-1809-2014
SPIN code
8071-5332

Publication list

  1. Krylov V.V., Guekht A.B., Trifonov I.S., Magomedsultanov A.I., Navruzov R.A., Lebedeva A.V., Rider F.K., Kaimovsky I.L., Sinkin M.V., Kordonskaia O.O., Nehoroshih A.E., Yakovlev A.A. EARLY AND LONG-TERM OUTCOMES OF SURGICAL TREATMENT OF PATIENTS WITH DRUGRESISTANT EPILEPSY. Russian Neurological Journal. 2022. V. 27. N. 1. P. 52-61. DOI: 10.30629/2658-7947-2022-27-1-52-61.
  2. Pashnin E.V., Zinchuk M.S., Gersamia A.G., Voinova N.I., Yakovlev A.A., Avedisova A.S., Guekht A.B. VERIFICATION OF REASONS FOR LIVING INVENTORY IN RUSSIAN CLINICAL SAMPLE. Psikhologicheskii Zhurnal. 2022. V. 43. N. 1. P. 109-121. DOI: 10.31857/S020595920017745-5.
  3. Yakovlev A.A. Neuroprotective Effects of Astrocyte Extracellular Vesicles in Stroke. Neurochemical Journal. 2022. V. 12. N. 2. P. 121-129. DOI: 10.1134/S1819712422020143.
  4. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Voinova N., Popova S., Sviatskaia E., Yakovlev A.A., Guekht A. Not always that EASI: Validating the Russian version of the epilepsy anxiety survey instrument and its brief counterpart. Epilepsy and Behavior. 2022. V. 133. DOI: 10.1016/j.yebeh.2022.108801.
  5. Yakovlev A.A., Antonov V., Druzhkova T., Guekht A.B., Gulyaeva N.V. Determination of Cholesterol and Triglyceride Concentrations in Serum Extracellular Vesicles Using Commercial Kits. Biomedical Chemistry: Research and Methods. 2021. V. 4. N. 2. e00148. DOI: 10.18097/BMCRM00148.
  6. Brylev L.V., Fominykh V.V., Chernenkaia V., Chernenkiy I., Gorbachev K., Ataulina A., Izvekov A., Monakhov M., Olenichev A., Orlov S., Turin I., Loginov M., Rautbart S., Baymukanov A., Parshikov V., Demeshonok V., Yakovlev A.A., Druzhkova T., Guekht A., Gulyaeva N.V. Stress load and neurodegeneration after gastrostomy tube placement in amyotrophic lateral sclerosis patients. Metabolic Brain Disease. 2021. V. 36. N. 8. P. 2473-2482. DOI: 10.1007/s11011-021-00837-x.
  7. Krylov V.V., Gekht A.B., Trifonov I.S., Lebedeva A.V., Rider F.K., Kaimovsky I.L., Sinkin M.V., Kordonskaya O.O., Magomedsultanov A.I., Navruzov R.A., Yakovlev A.A., Grigorieva E.V., Mamulashvili G.V. Long-term postoperative outcomes in patients with drug-resistant epilepsy. Zhurnal Voprosy Nejrokhirurgii Imeni N.N. Burdenko. 2021. V. 85. N. 5. P. 6-14. DOI: 10.17116/neiro2021850516.
  8. Kustov G.V., Zinchuk M.S., Gersamija A.G., Voinova N.I., Yakovlev A.A., Avedisova A.S., Guekht A.B. Psychometric properties of the Russian version of the brief «Reasons for Living Inventory». Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2021. V. 121. N. 10. P. 87-94. DOI: 10.17116/jnevro202112110187.
  9. Sinkin M.V., Talypov A.E., Yakovlev A.A., Kordonskaya O.O., Teplyshova A.M., Trifonov I.S., Guekht A.B., Krylov V.V. Long-term eeg monitoring in patients with acute traumatic brain injury. Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova. 2021. V. 121. N. 5. P. 62-67. DOI: 10.17116/jnevro202112105162.
  10. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Yakovlev A.A., Voinova N., Popova S., Avedisova A., Guekht A. Validation of the Generalized Anxiety Disorder-7 (GAD-7) in Russian people with epilepsy. Epilepsy &amp; Behavior. 2021. V. 123. P. 108269. DOI: 10.1016/j.yebeh.2021.108269.
  11. Zinchuk M.S., Kustov G., Pashnin E., Pochigaeva K., Rider F., Yakovlev A.A., Hesdorffer D., Hauser A.W., Guekht A. Interictal dysphoric disorder in people with and without epilepsy. . Epilepsia. 2021. V. 62. P. 1382-1390. DOI: 10.1111/epi.16902.
  12. Yakovlev A.A., Druzhkova T., Guekht A.B., Gulyaeva N.V. Sensitivity of Extracellular Vesicles from Human Blood Serum to Various Detergents. Biomedical Chemistry: Research and Methods. 2020. V. 3. N. 4. e00143. DOI: 10.18097/BMCRM00143.
  13. Rovnyagina N.R., Budylin G.S., Vainer Y.G., Tikhonova T.N., Vasin S.L., Yakovlev A.A., Kompanets V.O., Chekalin S.V., Priezzhev A.V., Shirshin E.A. Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements. International Journal Of Molecular Sciences. 2020. V. 21. N. 17. P. 6169. DOI: 10.3390/ijms21176169.
  14. Zinchuk M., Beghi M., Beghi E., Bianchi E., Avedisova A., Yakovlev A.A., Guekht A. Non-Suicidal Self-Injury in Russian Patients with Suicidal Ideation. Archives Of Suicide Research. 2020. V. 27. P. 1-25. DOI: 10.1080/13811118.2020.1833801.
  15. Zinchuk M., Kustov G., Pashnin E., Gersamia A., Rider F., Yakovlev A.A., Guekht A. Validation of the Russian version of neurological disorders depression inventory for epilepsy (NDDI-E). Epilepsy &amp; Behavior. 2020. V. 113. P. 107549. DOI: 10.1016/j.yebeh.2020.107549.
  16. Yakovlev A.A., Druzhkova T.A., Nikolaev R.V., Kuznetsova V.E., Gruzdev S.K., Guekht A.B., Gulyaeva N.V. Elevated Levels of Serum Exosomes in Patients with Major Depressive Disorder. Neurochemical Journal. 2019. V. 36. N. 4. P. 346-352. DOI: 10.1134/S1027813319040046.
  17. Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Exosomes secretion and autophagy in long-term protection of neurons from excitotoxic damage. Biomeditsinskaya Khimiya. 2019. V. 65. N. 5. P. 361-365. DOI: 10.18097/PBMC20196505361.
  18. Druzhkova T., Pochigaeva K., Yakovlev A.A., Gersamia A., Guekht A., Gulyaeva N.V. Effects of Childhood Trauma on the Biological Correlates of Stress in Men and Women with Borderline Mental Disorders. Neuroscience and Behavioral Physiology. 2019. V. 49. N. 7. P. 916-920. DOI: 10.1007/s11055-019-00819-8.
  19. Fominykh V.V., Brylev L.V., Gaskin V., Luzin R., Yakovlev A.A., Komoltsev I., Belousova I., Rosliakova A., Guekht A., Gulyaeva N.V. Neuronal damage and neuroinflammation markers in patients with autoimmune encephalitis and multiple sclerosis. Metabolic Brain Disease. 2019. V. 34. N. 5. P. 1473-1485. DOI: 10.1007/s11011-019-00452-x.
  20. Gruzdev S.K., Yakovlev A.A., Druzhkova T.A., Guekht A.B., Gulyaeva N.V. The Missing Link: How Exosomes and miRNAs can Help in Bridging Psychiatry and Molecular Biology in the Context of Depression, Bipolar Disorder and Schizophrenia. Cellular And Molecular Neurobiology. 2019. V. 39. N. 6. P. 729-750. DOI: 10.1007/s10571-019-00684-6.
  21. Druzhkova T.A., Yakovlev A.A. Exosome Drug Delivery Through The Blood–Brain Barrier:Experimental Approaches And Potential Applications. Neurochemical Journal. 2018. V. 35. N. 3. P. 201-211. DOI: 10.1134/S1027813318030032.
  22. Druzhkova T., Pochigaeva K., Yakovlev A.A., Kazimirova E., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers. Metabolic Brain Disease. 2018. V. 34. N. 2. P. 621-629. DOI: 10.1007/s11011-018-0367-3.
  23. Guekht A., Gersamiya A., Kaimovskiy I., Mizinova M., Yakovlev A.A., Shpak A. Attitudes towards people with epilepsy in Moscow. Epilepsy &amp; Behavior. 2017. V. 70. N. Pt A. P. 182-186. DOI: 10.1016/j.yebeh.2017.03.020.
  24. Pochigaeva K., Druzhkova T., Yakovlev A.A., Onufriev M.V., Grishkina M., Chepelev A., Guekht A., Gulyaeva N.V. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder. Metabolic Brain Disease. 2017. V. 32. N. 2. P. 577-583. DOI: 10.1007/s11011-017-9952-0.
  25. Yakovlev A.A., Lyzhin A.A., Khaspekov L.G., Guekht A.B., Gulyaeva N.V. Peptide drug cortexin inhibits brain caspase-8. Biomeditsinskaya Khimiya. 2017. V. 63. N. 1. P. 27-31. DOI: 10.18097/PBMC20176301027.
  26. Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Gekht A.B., Gulyaeva N.V. Activation of caspases in limphocytes of patients with border psychic disorders. Biomeditsynskaja Khimija. 2016. V. 62. N. 1. P. 89-92.
  27. Gersamia A.G., Menshikova A.A., Yakovlev A.A. Stress in childhood and psychological pecularities of humans under affective disorders. Eksperimentalnaja psikhologija. 2016. V. 9. N. 3. P. 103-117. DOI: 10.17759/exppsy.2016090308.
  28. Onufriev M.V., Semenova T.P., Volkova E.P., Sergunkina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal pecularitief of actine expression and CDK5 protein in different brain regions of Yakute gopher (Spermophilus Undulatus). Nejrokhimija. 2016. V. 33. N. 2. P. 103-111.
  29. Onufriev M.V., Semenova T.P., Volkova E.P., Yakovlev A.A., Sergulskaja M.A., Zakharova N.M., Gulyaeva N.V. Features of the expression of CDK1 protein and cyclin B1 in the brain of Yakut gophers (Spermophilus undulatus) at different stages of the hibernation cycle. Nejrokhimija. 2016. V. 33. N. 2. P. 112-121.
  30. Yakovlev A.A., Gulyaeva N.V. Cortexin's molecular partners in the brain. Nejrokhimija. 2016. V. 33. N. 4. P. 1-6.
  31. Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Caspase activity in peripheral blood mononuclear cells (PBMC) of patients with depression and anxiety of different severity. Biomeditsinskaya Khimiya. 2016. V. 62. N. 5. P. 588-592. DOI: 10.18097/PBMC20166205588.
  32. Yakovlev A.A., Lyzhin A.A., Aleksandrova O.P., Khaspekov L.G., Gulyaeva N.V. Trophic factors deprivation induces long-term protection of neurons against excitotoxic damage. Biomeditsinskaya Khimiya. 2016. V. 62. N. 6. P. 656-663. DOI: 10.18097/PBMC20166206656.
  33. Fominykh V., Onufriev M.V., Vorobyeva A., Brylev L., Yakovlev A.A., Zakharova M.N., Gulyaeva N.V. Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis. Journal of Clinical Neuroscience. 2016. V. 28. P. 38-42. DOI: 10.1016/j.jocn.2015.09.017.
  34. Gerasimovich E.S., Yakovlev A.A., Druzhkova T.A., Grishkina M.N., Guekht A.B., Gulyaeva N.V. Activation of caspases in lymphocytes of patients with borderline personality disorders. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2016. V. 10. N. 3. P. 246-250. DOI: 10.1134/S1990750816030021.
  35. Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. Seasonal changes in actin and Cdk5 expression in different brain regions of the Yakut ground squirrel (Spermophilus undulatus). Neurochemical Journal. 2016. V. 10. N. 2. P. 98-105. DOI: 10.1134/S1819712416020070.
  36. Onufriev M.V., Semenova T.P., Volkova E.P., Sergun'kina M.A., Yakovlev A.A., Zakharova N.M., Gulyaeva N.V. The characteristics of the expression of the Cdk1 and Cyclin B1 Proteins in the brain of the Yakut ground squirrel (Spermophilus undulatus) at different stages of the hibernation cycle. Neurochemical Journal. 2016. V. 10. N. 2. P. 106-114. DOI: 10.1134/S1819712416020082.
  37. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cellular and Molecular Neurobiology. 2016. V. 36. N. 6. P. 839-849. DOI: 10.1007/s10571-015-0267-6.
  38. Yakovlev A.A., Gulyaeva N.V. Preconditioning brain cells for pathological effects: the involvement of proteases. Biokhimija. 2015. V. 80. N. 2. P. 204-220.
  39. Freiman S.V., Onufriev M.V., Druzhkova T.A., Yakovlev A.A., Pochigaeva K.I., Chepelev A.V., Grishkina M.N., Gudkova A.A., Gekht A.B., Gulyaeva N.V. The change in blood glucose level after a moderate stress as a parameter of stress reactivity in anxiety and depression: A pilot translational study. Neurochemical Journal. 2015. V. 9. N. 2. P. 146-148. DOI: 10.1134/S1819712415020051.
  40. Yakovlev A.A., Gulyaeva N.V. Possible role of proteases in preconditioning of brain cells to pathological conditions. Biochemistry (Moscow). 2015. V. 80. N. 2. P. 163-171. DOI: 10.1134/S0006297915020030.
  41. Peregud D.I., Yakovlev A.A., Stepanichev M.Y., Onufriev M.V., Panchenko L.F., Gulyaeva N.V. Content of mRNA for NMDA glutamate receptor subunits in the frontal cortex and striatum of rats after morphine withdrawal is related to the degree of abstinence. Bull Exp Biol Med.. 2012. V. 153. N. 6. P. 835-838.
  42. Yakovlev A.A., Gulyaeva N.V. Pleiotropic functions of brain proteinases: Methodological considerations and search for caspase substrates. Biochemistry (Moscow). 2011. V. 76. N. 10. P. 1079-1086. DOI: 10.1134/S0006297911100014.
  43. Onufriev M.V., Yakovlev A.A., Lyzhin A.A., Stepanichev M.Y., Khaspekov L.G., Gulyaeva N.V. A secreted caspase-3-substrate-cleaving activity at low pH belongs to cathepsin B: A study on primary brain cell cultures. Biochemistry (Moscow). 2009. V. 74. N. 3. P. 281-287. DOI: 10.1134/S0006297909030067.
  44. Peregud D.I., Vorontsova O.N., Yakovlev A.A., Panchenko L.F., Gulyaeva N.V. Changes in anxiety in abstinence correlate with the state of the nigrostriatal system in the rat hippocampus. Neuroscience and Behavioral Physiology. 2008. V. 38. N. 5. P. 443-448. DOI: 10.1007/s11055-008-9000-y.
  45. Stepanichev M.Y., Onufriev M.V., Yakovlev A.A., Khrenov A.I., Peregud D.I., Vorontsova O.N., Lazareva N.A., Gulyaeva N.V. Amyloid-β (25-35) increases activity of neuronal NO-synthase in rat brain. Neurochemistry International. 2008. V. 52. N. 6. P. 1114-1124. DOI: 10.1016/j.neuint.2007.11.009.
  46. Yakovlev A.A., Gorokhovatsky A.Y., Onufriev M.V., Beletsky I.P., Gulyaeva N.V. Brain cathepsin B cleaves a caspase substrate. Biochemistry (Moscow0. 2008. V. 73. N. 3. P. 332-336.
  47. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Pentylenetetrazol kindling in rats: Is neurodegeneration associated with manifestations of convulsive activity?. Neuroscience and Behavioral Physiology. 2006. V. 36. N. 7. P. 741-748. DOI: 10.1007/s11055-006-0082-0.
  48. Stepanichev M.Y., Kudryashova I.V., Yakovlev A.A., Onufriev M.V., Khaspekov L.G., Lyzhin A.A., Lazareva N.A., Gulyaeva N.V. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience. 2005. V. 136. N. 2. P. 579-591. DOI: 10.1016/j.neuroscience.2005.08.010.
  49. Zarubenko I.I., Yakovlev A.A., Stepanichev M.Y., Gulyaeva N.V. Electroconvulsive shock induces neuron death in the mouse hippocampus: Correlation of neurodegeneration with convulsive activity. Neuroscience and Behavioral Physiology. 2005. V. 35. N. 7. P. 715-721. DOI: 10.1007/s11055-005-0115-0.
  50. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 9. P. 877-880. DOI: 10.1023/B:NEAB.0000042571.86110.28.
  51. Pavlova T.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritskii A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Neuroscience and Behavioral Physiology. 2004. V. 34. N. 1. P. 45-47. DOI: 10.1023/B:NEAB.0000003246.26997.10.
  52. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Caspase-3 inhibition blocks prolonged potentiation in hippocampal slices. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 537-540.
  53. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole kindling induces activation of caspase-3 in the rat brain. Zhurnal Vysshei Nervnoi Deiatelnosti im I P Pavlova. 2003. V. 53. P. 110-113.
  54. Yakovlev A.A., Peregud D.I., Egorova L.K., Panchenko L.F., Gulyaeva N.V. Caspase-3 activity in the brain regions of rats of Fischer-344 / N and WAG / G rats. Nejrokhimija. 2003. V. 20. P. 265-268.
  55. Stepanichev M.Y., Zdobnova I.M., Yakovlev A.A., Onufriev M.V., Lazareva N.A., Zarubenko I.I., Gulyaeva N.V. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35). Journal of Neuroscience Research. 2003. V. 71. N. 1. P. 110-120. DOI: 10.1002/jnr.10469.
  56. Zdobnova I.M., Stepanichev M.Y., Yakovlev A.A., Onufriev M.V., Egorova L.K., Moiseeva Y.V., Lazareva N.A., Matz V.N., Gulyaeva N.V. The interaction of the neurotoxic fragment of the beta-amyloid peptide and tumor necrosis factor alpha with intracerebral administration to rats. Nejrokhimija. 2002. V. 19. P. 117-122.
  57. Pavlova I.V., Yakovlev A.A., Stepanichev M.Y., Mendzheritsky A.M., Gulyaeva N.V. Pentylenetetrazole Kindling causes oxidative stress in rat brain. Nejrokhimija. 2002. V. 19. P. 123-126.
  58. Yakovlev A.A., Semenova T.P., Kolaeva S.G., Onufriev M.V., Mikhalea S.L., Gulyaeva N.V. Change in caspase-3 activity in the brain regions of gophers of Citellus undulatus during the hibernation cycle. Nejrokhimija. 2002. V. 19. 33-36.
  59. Kudryashov I.E., Yakovlev A.A., Kudryashova I.V., Gulyaeva N.V. Footshock stress alters early postnatal development of electrophysiological responses and caspase-3 activity in rat hippocampus. Neuroscience Letters. 2002. V. 332. N. 2. P. 95-98. DOI: 10.1016/S0304-3940(02)00937-0.
  60. Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Braun K.., Gulyaeva N.V. Caspase-3 activity in different parts of the brain of rodents. Nejrokhimija. 2001. V. 18. P. 41-43.
  61. Yakovlev A.A., Onufriev M.V., Stepanichev M.Y., Gulyaeva N.V. The effect of pentylenetetrazole on caspase-3 activity in the brain regions of mice. Nejrokhimija. 2001. V. 18. P. 191-194.
 

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