Each individual is characterized by a two-component Rayleigh distribution, which reflects two modes of movement: active movement (progression) and sedentary state (drift). A mechanical analogue would be the motion of a Brownian particle with a variable mass: small during active movement and large...

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Epigenetic rearrangements can create a favorable environment for the intrinsic plasticity of brain cells, leading to cellular reprogramming into virtually any cell type through the induction of cell-specific transcriptional programs. In this study, we assessed how chromatin remodeling induced by...

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Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less clear. We assessed effects of cortical spreading depolarization (CSD), the...

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The role of astrocytes in modulating synaptic plasticity is an important question that until recently was not addressed due to limitations of previously existing technology. In the present study, we took an advantage of optogenetics to specifically activate astrocytes in hippocampal slices in...

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Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These...

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Investigators were the first who visualized the full network of blood vessels in the neocortex of alert mice. They have found out that blood vessels are rhythmically extended and contracted resulting to spreading "waves across the brain surface. Physiological function of such waves remain to be...

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The new format of online communications, which came to us during the pandemic, has become firmly entrenched in our lives, especially in the fields of education and business. On the one hand, we have received more freedom and opportunities, on the other hand, many are dissatisfied with the remote...

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Primary sensory areas in the vertebrate neocortex (visual, auditory, somatosensory) is a central region of corresponding sensory analyzer. It was considered for a long time that such regions provide exact coding if visual information and thus doesn't undergo plasticity. However, several types of...

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Currently, practically nothing is known about the biological processes occurring in the brain in most mental pathologies. One such pathology is non-suicidal self-injury (NSSI). Researchers from the IHNA&NPh RAS and the Moscow Research and Clinical Center for Neuropsychiatry have outlined a new...

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Extracellular vesicles (EVs) are a new and actively developing area of modern experimental and theoretical biology, which attracts researchers primarily by the possibility of using EVs as diagnostic biomarkers and therapeutic agents. Currently, the largest amount of data has been accumulated on...

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