18.06.2012

Журнальный клуб 20.06.2012

20 июня в 15:00 в конференц-зале ИВНД и НФ состоится заседание Журнального клуба. Доклад подготовит Ольга Минеева на основе статьи: Experience Dictates Stem Cell Fate in the Adult Hippocampus. Alex Dranovsky, Alyssa M. Picchini, Tiffany Moadel, Alexander C. Sisti, Atsushi Yamada, Shioko Kimura, E. David Leonardo, and Rene Hen Neuron 70, 908–923, June 9, 2011

Adult hippocampal neurogenesis has been implicated in cognitive and emotional processes, as well as in response to antidepressant treatment. However, little is known about how the adult stem cell lineage contributes to hippocampal structure and function and how this process is modulated by the animal’s experience. Here weperform an indelible lineage analysis and report that neural stem cells can produce expanding and persisting populations of not only neurons, but also stem cells in the adult hippocampus. Furthermore, the ratio of stem cells to neurons depends on experiences of the animal or the location of the stem cell. Surprisingly, social isolation facilitated accumulation of stem cells, but not neurons. These results show that neural stem cells accumulate in the adult hippocampus and that the stem cell-lineage relationship is under control of anatomic and experiential niches. Our findings suggest that, in the hippocampus, fate specification may act as a form of cellular plasticity for adapting to environmental changes.


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