Журнальный клуб 20.06.2012
20 июня в 15:00 в конференц-зале ИВНД и НФ состоится заседание Журнального клуба. Доклад подготовит Ольга Минеева на основе статьи: Experience Dictates Stem Cell Fate in the Adult Hippocampus. Alex Dranovsky, Alyssa M. Picchini, Tiffany Moadel, Alexander C. Sisti, Atsushi Yamada, Shioko Kimura, E. David Leonardo, and Rene Hen Neuron 70, 908–923, June 9, 2011
Adult hippocampal neurogenesis has been implicated
in cognitive and emotional processes, as
well as in response to antidepressant treatment.
However, little is known about how the adult stem
cell lineage contributes to hippocampal structure
and function and how this process is modulated by
the animal’s experience. Here weperform an indelible
lineage analysis and report that neural stem cells can
produce expanding and persisting populations of not
only neurons, but also stem cells in the adult hippocampus.
Furthermore, the ratio of stem cells to
neurons depends on experiences of the animal or
the location of the stem cell. Surprisingly, social isolation
facilitated accumulation of stem cells, but not
neurons. These results show that neural stem cells
accumulate in the adult hippocampus and that the
stem cell-lineage relationship is under control of
anatomic and experiential niches. Our findings
suggest that, in the hippocampus, fate specification
may act as a form of cellular plasticity for adapting
to environmental changes.